Evidence map›Paper›PMID 35054452›Full record

ReviewLife (Basel, Switzerland)2022

An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer.

Vidya Sankarapandian, Balu Alagar Venmathi Maran, Ramya Lakshmi Rajendran, Manasi P Jogalekar, Sridharan Gurunagarajan, Rajapandiyan Krishnamoorthy, Prakash Gangadaran, Byeong-Cheol Ahn

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Iranian journal of microbiology · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Lipopeptides fromBiotech (Basel (Switzerland)) · 2026
    Article
  7. The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Application and Challenges of Using ProbioticDiseases (Basel, Switzerland) · 2025
    Review
  12. Review
  13. Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.International journal of molecular sciences · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vidya SankarapandianDepartment of Microbiology, Srimad Andavan Arts and Science College, Bharathidasan University, Trichy 620005, India.
Balu Alagar Venmathi MaranBorneo Marine Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia.ORCID 0000-0003-1090-5295
Ramya Lakshmi RajendranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0001-6987-0854
Manasi P JogalekarHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA.
Sridharan GurunagarajanDepartment of Biochemistry, Srimad Andavan Arts and Science College, Bharathidasan University, Trichy 620005, India.ORCID 0000-0003-4861-6050
Rajapandiyan KrishnamoorthyNanobiotechnology and Molecular Biology Research Lab, Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh 4545, Saudi Arabia.
Prakash GangadaranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0002-0658-4604
Byeong-Cheol AhnDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0001-7700-3929

Funding

National Research Foundation of Korea NRF-2019R1I1A1A01061296National Research Foundation of Korea NRF-2019R1I1A3A01063308National Research Foundation of Korea NRF-2021R1I1A1A01040732
6 · The paper itself

Abstract

Probiotics are living microbes that play a significant role in protecting the host in various ways. Gut microbiota is one of the key players in maintaining homeostasis. Cancer is considered one of the most significant causes of death worldwide. Although cancer treatment has received much attention in recent years, the number of people suffering from neoplastic syndrome continues to increase. Despite notable improvements in the field of cancer therapy, tackling cancer has been challenging due to the multiple properties of cancer cells and their ability to evade the immune system. Probiotics alter the immunological and cellular responses by enhancing the epithelial barrier and stimulating the production of anti-inflammatory, antioxidant, and anticarcinogenic compounds, thereby reducing cancer burden and growth. The present review focuses on the various mechanisms underlying the role of probiotics in the prevention and treatment of cancer.

Indexed as

biotherapyimmunomodulationmetastasisoncogene kinaseprobiotics

Identifiers

PMID35054452
PMCPMC8779143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.