Evidence map›Paper›PMID 35054378›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Impact of Antibiotic Prophylaxis on Infection Rate after Endoscopic Ultrasound Through-the-Needle Biopsy of Pancreatic Cysts: A Propensity Score-Matched Study.

Antonio Facciorusso, Martha Arevalo-Mora, Maria Cristina Conti Bellocchi, Laura Bernardoni, Daryl Ramai, Paraskevas Gkolfakis, Domenico Loizzi, Nicola Muscatiello, Antonio Ambrosi, Nicola Tartaglia and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06535490 (Prevention of Infection After EUS-FNA of Pancreatic Cystic Lesions), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06535490 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Prevention of Infection After EUS-FNA of Pancreatic Cystic Lesions: A French Multicenter Prospective Comparative Observational Study

TypeobservationalSponsorSociété Française d'Endoscopie DigestiveRan2024 to 2027Enrolled1,702ConditionsPancreatic Cystic LesionArmsEUS-FNA, ATBp
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Antonio FacciorussoGastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-2107-2156
Martha Arevalo-MoraInstituto Ecuatoriano de Enfermedades Digestivas, Guayaquil 090505, Ecuador.
Maria Cristina Conti BellocchiGastroenterology and Digestive Endoscopy Unit, Department of Medicine, The Pancreas Institute, University Hospital of Verona, 37134 Verona, Italy.
Laura BernardoniGastroenterology and Digestive Endoscopy Unit, Department of Medicine, The Pancreas Institute, University Hospital of Verona, 37134 Verona, Italy.
Daryl RamaiDivision of Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, UT 84112, USA.
Paraskevas GkolfakisDepartment of Gastroenterology, Hepatopancreatology, and Digestive Oncology, CUB Erasme Hospital, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.ORCID 0000-0002-9677-4013
Domenico LoizziThoracic Surgery Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Nicola MuscatielloGastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Antonio AmbrosiGeneral Surgery Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Nicola TartagliaGeneral Surgery Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-6845-7080
Carlos Robles-MedrandaInstituto Ecuatoriano de Enfermedades Digestivas, Guayaquil 090505, Ecuador.
Elisa StasiGastroenterology and Digestive Endoscopy, 'Vito Fazzi' Hospital, 73100 Lecce, Italy.ORCID 0000-0001-9919-2660
Andrew OfosuDivision of Digestive Diseases, University of Cincinnati, Cincinnati, OH 45221, USA.
Stefano Francesco CrinòGastroenterology and Digestive Endoscopy Unit, Department of Medicine, The Pancreas Institute, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0003-4560-8741
University of Foggia · ITUniversity of Verona · ITInstituto Ecuatoriano de Enfermedades Digestivas · ECOspedale Vito Fazzi · ITUniversité Libre de Bruxelles · BEUniversity of Cincinnati · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite weak evidence, antibiotic prophylaxis prior to endoscopic ultrasound-guided through-the-needle biopsy (EUS-TTNB) of pancreatic cystic lesions (PCLs) is routinely used in clinical practice. We aim to compare a group of patients treated with antibiotics before EUS-TTNB of PCLs and a group who did not undergo antimicrobial prophylaxis.

methodsOut of 236 patients with pancreatic cystic lesions referred to two high-volume centers between 2016 and 2021, after propensity score matching, two groups were compared: 98 subjects who underwent EUS-TTNB under antibiotic prophylaxis and 49 subjects without prophylaxis.

resultsThere was no difference in terms of baseline parameters between groups. Final diagnosis was serous cystadenoma in 36.7% of patients in the group not treated with prophylaxis and in 37.7% of patients in the control group, whereas IPMN and mucinous cystadenoma were diagnosed in 3 (6.1%) and 16 (32.6%) versus 6 (6.1%) and 32 (32.6%) patients in the two groups, respectively (

conclusionsProphylactic antibiotics do not seem to influence the risk of infection, and their routine use should be discouraged.

Indexed as

antibioticsendoscopic ultrasoundpancreasthrough-the-needle biopsy

Identifiers

PMID35054378
PMCPMC8774428
OpenAlexW4206591271

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.