Evidence map›Paper›PMID 35054350›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Biomarkers in EndoVascular Aneurysm Repair (EVAR) and Abdominal Aortic Aneurysm: Pathophysiology and Clinical Implications.

Francesco Stilo, Vincenzo Catanese, Antonio Nenna, Nunzio Montelione, Francesco Alberto Codispoti, Emanuele Verghi, Teresa Gabellini, Mohamad Jawabra, Massimo Chello, Francesco Spinelli

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Journal of thoracic disease · 2024
    Article
  6. Article
  7. NADPH Oxidases in Aortic Aneurysms.Antioxidants (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Francesco StiloDepartment of Vascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Vincenzo CataneseDepartment of Vascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Antonio NennaDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0002-4069-6781
Nunzio MontelioneDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Francesco Alberto CodispotiDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Emanuele VerghiDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Teresa GabelliniResidency Program of Vascular and Endovascular Surgery, University of Ferrara, 44121 Ferrara, Italy.
Mohamad JawabraDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Massimo ChelloDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0001-8178-7068
Francesco SpinelliDepartment of Cardiovascular Surgery, Campus Bio-Medico University, 00128 Rome, Italy.
Università Campus Bio-Medico · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating biomarkers have been recently investigated among patients undergoing endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA). Considering the plethora of small descriptive studies reporting potential associations between biomarkers and clinical outcomes, this review aims to summarize the current literature considering both the treated disease (post EVAR) and the untreated disease (AAA before EVAR). All studies describing outcomes of tissue biomarkers in patients undergoing EVAR and in patients with AAA were included, and references were checked for additional sources. In the EVAR scenario, circulating interleukin-6 (IL-6) is a marker of inflammatory reaction which might predict postoperative morbidity; cystatin C is a promising early marker of post-procedural acute kidney injury; plasma matrix metalloproteinase-9 (MMP-9) concentration after 3 months from EVAR might help in detecting post-procedural endoleak. This review also summarizes the current gaps in knowledge and future direction of this field of research. Among markers used in patients with AAA, galectin and granzyme appear to be promising and should be carefully investigated even in the EVAR setting. Larger prospective trials are required to establish and evaluate prognostic models with highest values with these markers.

Indexed as

abdominal aortic aneurysmbiomarkerscystatin Cendoleakendovascular aortic aneurysm repairinterleukin-6matrix metalloproteinases

Identifiers

PMID35054350
PMCPMC8774611
OpenAlexW4205244566

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.