ArticleDiagnostics (Basel, Switzerland)2022
Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Predictors of thyroid cancer in paediatric patients with thyroid nodules: A systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Thyroid function disorders and secondary cancer following haematopoietic stem cell transplantation in pediatrics: State of the art and practical recommendations for a risk-based follow-up.Frontiers in endocrinology · 2022Pooled it
- The Role of Cytology, Histology and Molecular Pathology in the Diagnostic Process of Thyroid Nodules.Cancers · 2026Review
- The correlation between fine needle aspiration diagnosis and postoperative histopathological results of pediatric thyroid nodules based on the Bethesda system.Frontiers in endocrinology · 2026Article
- Comparison of Cytological, Histopathological, and Imaging Findings Based on 10 mm Threshold in Pediatric Thyroid Nodules.Children (Basel, Switzerland) · 2025Article
- Toward Standardized Management of Indeterminate Thyroid Nodules in Pediatric Patients: A Systematic Review and Call for a Comprehensive Risk Stratification Model.Journal of clinical medicine · 2025Review
- Approach to the Pediatric Patient With Thyroid Nodules.The Journal of clinical endocrinology and metabolism · 2025Review
- Thyroid cytology in pediatric patients: a single-center study from 2015 to 2023-is there a necessity for distinct treatment approaches for patients with and without autoimmune thyroiditis?Virchows Archiv : an international journal of pathology · 2025Article
- Cytopathology of follicular and oncocytic follicular thyroid neoplasms: A Bethesda System perspective.Cancer cytopathology · 2025Review
- The diagnostic role of FNA based on clinicopathological features in thyroid malignancy.BMC endocrine disorders · 2025Article
- Two Decades of Thyroid Nodule Cytology in Children: Malignancy Risk Assessment at a Tertiary Care Center.Hormone research in paediatrics · 2025Article
- Evaluating Postoperative Outcomes and Investigating the Usefulness of EU-TIRADS Scoring in Managing Pediatric Thyroid Nodules Bethesda 3 and 4Journal of clinical research in pediatric endocrinology · 2024Article
- Evolving approaches in paediatric thyroid cytopathology: A review.Cytopathology : official journal of the British Society for Clinical Cytology · 2024Review
- Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk of malignancy ratios (ROMs) was given in ranges and calculated by 2 different ways. Sensitivity, specificity, PPV, NPV and DA ratios were calculated using histologic diagnosis as the gold standard; Results: Among a total of 405 specimens, the distribution of cases for each category was, 44 (11%) for ND, 204 (50%) for B category, 40 (10%) for AUS/FLUS, 36 (9%) for FN/SFN, 24 (6%) for SFM and 57 (14%) for M categories. 153 cases have a histological diagnosis. The ratio of surgery was 23% in ND, 16% in the B, 45% for AUS/FLUS, 75% for SFN/FN and 92% for SFM and 75% in M categories; Conclusions: The data underlines the high ROM values in paediatric population which might be clinically meaningful. The high rate of malignancy of the cohort of operated patients (50%) also underlines the need of better preoperative indicators for stratification. Considering that more than half of the nodules in AUS/FLUS category were benign, direct surgery recommendation could be questionable as proposed in ATA 2015 guidelines.
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