ArticleDiagnostics (Basel, Switzerland)2021
Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Risk Stratification and Ventilator Liberation in Neuromyelitis Optica Spectrum Disorder-Related Central Respiratory Failure.Neurocritical care · 2026Article
- Enhanced Moisture-Focused, Nurse-Led Oral Care Improves Oral Health and Suppresses Bacterial Overgrowth in Mechanically Ventilated ICU Patients: A Quasi-Experimental Study.Nursing in critical care · 2026Article
- Lung ultrasound score versus HACOR score as a predictor for weaning outcome in patients at high risk for extubation failure.Lung India : official organ of Indian Chest Society · 2025Article
- The Additional Prognostic Value of Serial Biomarker Measurements for Extubation Failure Among Patients With COVID-19 Acute Respiratory Distress Syndrome.Biomarker insights · 2025Article
- Predicting Successful Weaning through Sonographic Measurement of the Rapid Shallow Breathing Index.Journal of clinical medicine · 2024Article
- Biomarkers of Sepsis.Diagnostics (Basel, Switzerland) · 2023Article
- The Predictive Value of Heparin-Binding Protein and D-Dimer in Patients with Sepsis.International journal of general medicine · 2023Article
- A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeptic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous breathing trial (SBT) in these patients.
methodsSixty-five patients on MV (42 septic and 23 intubated for other reasons) fulfilling the criteria for SBT were included in the study. Blood samples were collected right before, at the end of (30 min) and 24 h after the SBT. Serum inflammatory mediators associated with sepsis (IL-18, IL-18BP, TNF) were determined and correlated with the outcome of SBT.
resultsA successful SBT was achieved in 45 patients (69.2%). Septic patients had a higher percentage of SBT failure as compared to non-septic patients (85% vs. 15%,
conclusionSustained increased levels of IL-18 and IL-18BP, acknowledged markers of sepsis, were found to be indicative of SBT failure in patients recovering from sepsis. Our results show that, although subclinical, remaining septic inflammation that sustaines for a long time complicates the weaning procedure. Biomarkers for the estimation of the septic burden and the right time for weaning are needed.
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