Evidence map›Paper›PMID 35054204›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation-Experimental Study.

Tomasz Urbanowicz, Anna Olasińska-Wiśniewska, Michał Michalak, Michał Rodzki, Anna Witkowska, Ewa Straburzyńska-Migaj, Bartłomiej Perek, Marek Jemielity

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tomasz UrbanowiczCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0001-8080-2764
Anna Olasińska-WiśniewskaCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0002-4213-8708
Michał MichalakDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0002-2852-3984
Michał RodzkiCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Anna WitkowskaCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0002-1642-2342
Ewa Straburzyńska-Migaj1st Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Bartłomiej PerekCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0003-2398-9571
Marek JemielityCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Poznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory reactions activation and may play a clinical role as a predictive marker in oncological and cardiovascular diseases. The aim of the study was to find simple hematologic indices available from whole blood count to help in immunosuppressive therapy monitoring. (2) Methods: Thirty patients (23 men and 7 women) with a mean age of 43 +/- 13 years who had undergone orthotopic heart transplantation were enrolled into the study. The blood samples for whole blood count and Tacrolimus level were collected during outpatient visits in heart transplant recipients every two months for 18 months after first year post transplantation. (3) Results: There was a significant correlation between Tacrolimus overdose (>15 ng/mL) and NLR (Spearman's rho 0.99,

Indexed as

drug overdoseheart transplantationMPVNLRtacrolimus

Identifiers

PMID35054204
PMCPMC8774838
OpenAlexW4200503062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.