Evidence map›Paper›PMID 35054052›Full record

ArticleJournal of clinical medicine2022

Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?

Francesco Latini, Markus Fahlström, Fredrik Vedung, Staffan Stensson, Elna-Marie Larsson, Mark Lubberink, Yelverton Tegner, Sven Haller, Jakob Johansson, Anders Wall and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Francesco LatiniSection of Neurosurgery, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden.ORCID 0000-0002-4702-526X
Markus FahlströmSection of Radiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.ORCID 0000-0002-2502-6026
Fredrik VedungSection of Neurosurgery, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden.
Staffan StenssonRehabilitation and Pain Centre, Uppsala University Hospital, 75185 Uppsala, Sweden.
Elna-Marie LarssonSection of Radiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.
Mark LubberinkPET Centre, Uppsala University Hospital, 75185 Uppsala, Sweden.
Yelverton TegnerDivision of Health, Medicine and Rehabilitation, Department of Health, Education and Technology, Luleå University of Technology, 97187 Luleå, Sweden.ORCID 0000-0003-3628-0705
Sven HallerSection of Radiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.ORCID 0000-0001-7433-0203
Jakob JohanssonSection of Anesthesiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.
Anders WallPET Centre, Uppsala University Hospital, 75185 Uppsala, Sweden.
Gunnar AntoniDepartment of Medicinal Chemistry, Uppsala University, 75185 Uppsala, Sweden.
Niklas MarklundSection of Neurosurgery, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden.
Uppsala University · SEUppsala University Hospital · SELuleå University of Technology · SE

Funding

Swedish Brain Foundation FO2020-0147, FO2019-0190, FO2018-0166,Swedish center for sports medicine P2019-0133,P2020-0116,P2021-0105Swedish research council 2018-02500_VR
6 · The paper itself

Abstract

Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of post-injury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (

Indexed as

diffusion tensor imagingmemory impairmentrehabilitative approachessport related concussiontraumatic brain injurywhite matter lesions

Identifiers

PMID35054052
PMCPMC8780504
OpenAlexW4205882225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.