Evidence map›Paper›PMID 35054031›Full record

ArticleJournal of clinical medicine2022

Serendipitous Stimulation of Nucleus Basalis of Meynert-The Effect of Unintentional, Long-Term High-Frequency Stimulation on Cognition in Parkinson's Disease.

I Daria Bogdan, D L Marinus Oterdoom, Teus van Laar, Rients B Huitema, Vincent J Odekerken, Judith A Boel, Rob M A de Bie, J Marc C van Dijk, On Behalf Of The Nstaps Study Group

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

I Daria BogdanDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.
D L Marinus OterdoomDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.
Teus van LaarDepartment of Neurology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.
Rients B HuitemaDepartment of Neurology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.
Vincent J OdekerkenDepartment of Neurology, Amsterdam Neuroscience Institute, Amsterdam University Medical Center, 1105 Amsterdam, The Netherlands.
Judith A BoelDepartment of Neurology, Amsterdam Neuroscience Institute, Amsterdam University Medical Center, 1105 Amsterdam, The Netherlands.
Rob M A de BieDepartment of Neurology, Amsterdam Neuroscience Institute, Amsterdam University Medical Center, 1105 Amsterdam, The Netherlands.
J Marc C van DijkDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.ORCID 0000-0002-0814-5680
On Behalf Of The Nstaps Study Group
University Medical Center Groningen · NLAmsterdam Neuroscience · NL

Funding

Parkinsonvereniging 2011-V04Prinses Beatrix Fonds War05-0203Stichting Internationaal Parkinsonfonds n.a.
6 · The paper itself

Abstract

There is a growing interest in deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) as a potential therapeutic modality for Parkinson's disease dementia (PDD). Low-frequency stimulation has yielded encouraging results in individual patients; however, these are not yet sustained in larger studies. With the aim to expand the understanding of NBM-DBS, we share our experience with serendipitous NBM-DBS in patients treated with DBS of the internal Globus pallidus (GPi) for Parkinson's disease. Since NBM is anatomically located ventral to GPi, several GPi-treated patients appeared to have the distal contact of DBS-electrode(s) positioned in the NBM. We hypothesized that unintentional high-frequency NBM-DBS over a period of one year would result in the opposite effect of low-frequency NBM-stimulation and cause cognitive decline. We studied a cohort of 33 patients with bilateral high-frequency DBS in the GPi for Parkinson's disease, of which twelve were unintentionally co-stimulated in NBM. The subgroups of unintentional unilateral (

Indexed as

cognitive functioncognitive impairmentsdeep brain stimulationParkinson’s diseaseParkinson’s disease dementia

Identifiers

PMID35054031
PMCPMC8779041
OpenAlexW4205630528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.