ArticleBrain sciences2022
Restless Legs Syndrome: Known Knowns and Known Unknowns.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Selective impairment of affective theory of mind in restless legs syndrome: a case-control study.Arquivos de neuro-psiquiatria · 2026Article
- Altered Sensory Processing in Restless Legs Syndrome: Associations With Disease Severity.Brain and behavior · 2026Article
- Thermoregulation in Sleep Disorders-Comprehensive Review.Journal of clinical medicine · 2026Review
- Plasma Membrane Lipid Composition and Turnover in Human Midbrain Neurons Investigated by Time-of-Flight Mass Spectrometry.Biomolecules · 2025Article
- Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- "Restless Nights, Stressed Hearts": The Link Between Sleep Disorders and Takotsubo Syndrome-A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology.Sleep science (Sao Paulo, Brazil) · 2024Article
- A survey-based approach on restless legs syndrome: practices and perspectives among Italian neurologists.Journal of neurology · 2024Article
- Restless leg syndrome as a complication of primary hyperparathyroidism: insights from a retrospective study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Correlates of Restless Legs Syndrome in Older People.Journal of clinical medicine · 2024Article
- Reduced Interoception Abilities in Patients with Restless Legs Syndrome.Movement disorders clinical practice · 2023Article
- Restless leg syndrome in spinal cord injury: case report.Spinal cord series and cases · 2023Article
- Leg restlessness and hyperparathyroidism in Parkinson's disease, a further clue to RLS pathogenesis?Frontiers in neurology · 2023Article
- Treatment initiation and utilization patterns of pharmacotherapies for early-onset idiopathic restless legs syndrome.Sleep medicine · 2022Article
- The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although restless legs syndrome (RLS) is a common neurological disorder, it remains poorly understood from both clinical and pathophysiological perspectives. RLS is classified among sleep-related movement disorders, namely, conditions characterized by simple, often stereotyped movements occurring during sleep. However, several clinical, neurophysiological and neuroimaging observations question this view. The aim of the present review is to summarize and query some of the current concepts (known knowns) and to identify open questions (known unknowns) on RLS pathophysiology. Based on several lines of evidence, we propose that RLS should be viewed as a disorder of sensorimotor interaction with a typical circadian pattern of occurrence, possibly arising from neurochemical dysfunction and abnormal excitability in different brain structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.