Evidence map›Paper›PMID 35053817›Full record

ArticleBrain sciences2022

Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study.

Doaa A Mekkawy, Sherif Hamdy, Maged Abdel-Naseer, Hatem S Shehata, Ahmed Al Halfawy, Nevin M Shalaby, Ghaydaa A Shehata, Anwar M Ali, Alaa Elmazny, Sandra M Ahmed and 22 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 5 institutions in 5 countries.

Doaa A MekkawyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Sherif HamdyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0001-6961-8675
Maged Abdel-NaseerDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0002-2053-980X
Hatem S ShehataDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Ahmed Al HalfawyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Nevin M ShalabyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Ghaydaa A ShehataDepartment of Neurology, Assuit University Hospitals, Assuit 71515, Egypt.
Anwar M AliDepartment of Neurology, Assuit University Hospitals, Assuit 71515, Egypt.
Alaa ElmaznyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Sandra M AhmedDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Jumana H IsmailDepartment of Chest Diseases, Cairo University Hospitals, Cairo 11511, Egypt.
Aml IbraheimDepartment of Chest Diseases, Cairo University Hospitals, Cairo 11511, Egypt.
Hoda M Abdel-HamidDepartment of Chest Diseases, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0003-4536-7941
Rehab MagdyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0002-4916-276X
Younan Kabara AyoubEndemic Medicine Department, Cairo University Hospitals, Cairo 11511, Egypt.
Ahmed E TahaEndemic Medicine Department, Cairo University Hospitals, Cairo 11511, Egypt.
Nahla MerghanyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Nourhan M SolimanDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Haidy ElshebawyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Samar E S AbdelalDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Lobna El-GhoneimyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Aussan Al-AthwariDepartment of Neurology, Aden University, Aden 37970, Yemen.ORCID 0000-0001-5988-0952
Nirmeen A KishkDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Mona A F NadaDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Marwa FarghalyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Amr HassanDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0001-7374-7074
Mohamed I HegazyDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0001-5012-3998
Ahmed AbdelalimDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Husam S MouradDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.
Amira HassounaFaculty of Health and Environmental Sciences, School of Public Health and Interdisciplinary Studies, Auckland University of Technology, Auckland 1142, New Zealand.
Alshimaa S OthmanDepartment of Neurology, Cairo University Hospitals, Cairo 11511, Egypt.ORCID 0000-0003-0976-9011
Tissa WijeratneDepartment of Medicine and Neurology, AIMSS, Melbourne Medical School, Sunshine Hospital, Western Health, St Albans, VIC 3021, Australia.ORCID 0000-0002-1701-7111
Cairo University hospitals · EGAssiut University Hospitals · EGAuckland University of Technology · NZLa Trobe University · AUUniversity of Aden · YE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic has reached over 276 million people globally with 5.3 million deaths as of 22nd December 2021. COVID-19-associated acute and long-term neurological manifestations are well recognized. The exact profile and the timing of neurological events in relation to the onset of infection are worth exploring. The aim of the current body of work was to determine the frequency, pattern, and temporal profile of neurological manifestations in a cohort of Egyptian patients with confirmed COVID-19 infection.

methodsThis was a prospective study conducted on 582 hospitalized COVID-19 patients within the first two weeks of the diagnosis of COVID-19 to detect any specific or non-specific neurological events.

resultsThe patients' mean (SD) age was 46.74 (17.26) years, and 340 (58.42%) patients were females. The most commonly encountered COVID-19 symptoms were fever (90.72%), cough (82.99%), and fatigue (76.98%). Neurological events (NE) detected in 283 patients (48.63%) and were significantly associated with a severe COVID-19 at the onset (OR: 3.13; 95% CI: 2.18-4.51;

conclusionsNeurological involvement is common (48.63%) in COVID-19 patients within the first two weeks of the illness. This includes neurological symptoms such as anosmia, headaches, as well as a constellation of neurological syndromes such as stroke, encephalitis, transverse myelitis, and Guillain-Barré syndrome. Severity of acute COVID-19 illness and older age are the main risk factors.

Indexed as

COVID-19neurological disordersserial systemic immune inflammatory indices (SSIIi)stroke

Identifiers

PMID35053817
PMCPMC8773531
OpenAlexW4206762085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.