Evidence map›Paper›PMID 35053751›Full record

ArticleBrain sciences2021

The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders.

Dorota Frydecka, Błażej Misiak, Patryk Piotrowski, Tomasz Bielawski, Edyta Pawlak, Ewa Kłosińska, Maja Krefft, Kamila Al Noaimy, Joanna Rymaszewska, Ahmed A Moustafa and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Genes · 2024
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Dorota FrydeckaDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.ORCID 0000-0001-8582-9958
Błażej MisiakDepartment of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.
Patryk PiotrowskiDepartment of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.ORCID 0000-0001-7208-0562
Tomasz BielawskiDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.
Edyta PawlakDepartment of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigel Street 12, 53-114 Wroclaw, Poland.ORCID 0000-0002-0386-7940
Ewa KłosińskaDay-Care Psychiatric Unit, University Clinical Hospital, Pasteur Street 10, 50-367 Wroclaw, Poland.
Maja KrefftDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.
Kamila Al NoaimyDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.
Joanna RymaszewskaDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.
Ahmed A MoustafaSchool of Psychology, Marcs Institute for Brain and Behaviour, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia.
Jarosław DrapałaDepartment of Computer Science and Systems Engineering, Faculty of Information and Communication Technology, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego Street 27, 50-370 Wrocław, Poland.
Wroclaw Medical University · PLPolish Academy of Sciences · PLUniversity of Johannesburg · ZAWrocław University of Science and Technology · PL

Funding

National Science Center DEC-2013/11/D/HS6/04619
6 · The paper itself

Abstract

Schizophrenia spectrum disorders (SZ) are characterized by impairments in probabilistic reinforcement learning (RL), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia. However, there are no studies examining dopaminergic genes with respect to probabilistic RL in SZ. Thus, the aim of our study was to examine the impact of dopaminergic genes on performance assessed by the Probabilistic Selection Task (PST) in patients with SZ in comparison to healthy control (HC) subjects. In our study, we included 138 SZ patients and 188 HC participants. Genetic analysis was performed with respect to the following genetic polymorphisms: rs4680 in

Indexed as

basal gangliaprefrontal cortexprobabilistic learning taskreinforcement learningschizophreniastriatum

Identifiers

PMID35053751
PMCPMC8774082
OpenAlexW4200393408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.