Evidence map›Paper›PMID 35053745›Full record

ArticleBrain sciences2021

Neural Correlates of Letter and Semantic Fluency in Primary Progressive Aphasia.

Marianna Riello, Constantine E Frangakis, Bronte Ficek, Kimberly T Webster, John E Desmond, Andreia V Faria, Argye E Hillis, Kyrana Tsapkini

Abstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marianna RielloDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6889-9241
Constantine E FrangakisDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 21227, USA.
Bronte FicekDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Kimberly T WebsterDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
John E DesmondDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Andreia V FariaDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21227, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Kyrana TsapkiniDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
Transcranial direct current stimulation in typical and atypical Alzheimer's diseaseR01AG068881 · NIA · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2020 to 2024
$3.8M
Statistical methods for characterizing patients who highly-benefit from treatments and programs in Alzheimers, HIV, and other heterogeneous diseasesR01AI140854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI FRANGAKIS, CONSTANTINE E · 2018 to 2021
$1.8M
NIAID NIH HHS R01 AI140854NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG068881NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

Verbal fluency (VF) is an informative cognitive task. Lesion and functional imaging studies implicate distinct cerebral areas that support letter versus semantic fluency and the understanding of neural and cognitive mechanisms underlying task performance. Most lesion studies include chronic stroke patients. People with primary progressive aphasia (PPA) provide complementary evidence for lesion-deficit associations, as different brain areas are affected in stroke versus PPA. In the present study we sought to determine imaging, clinical and demographic correlates of VF in PPA. Thirty-five patients with PPA underwent an assessment with letter and category VF tasks, evaluation of clinical features and an MRI scan for volumetric analysis. We used stepwise regression models to determine which brain areas are associated with VF performance while acknowledging the independent contribution of clinical and demographic factors. Letter fluency was predominantly associated with language severity (R

Indexed as

category fluencygrey matter volumesletter fluencyphonological fluencyprimary progressive aphasiasemantic fluency

Identifiers

PMID35053745
PMCPMC8773895

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.