Evidence map›Paper›PMID 35053608›Full record

ArticleCancers2022

A Few-Shot Learning Approach Assists in the Prognosis Prediction of Magnetic Resonance-Guided Focused Ultrasound for the Local Control of Bone Metastatic Lesions.

Fang-Chi Hsu, Hsin-Lun Lee, Yin-Ju Chen, Yao-An Shen, Yi-Chieh Tsai, Meng-Huang Wu, Chia-Chun Kuo, Long-Sheng Lu, Shauh-Der Yeh, Wen-Sheng Huang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Exploring SGLT2 Inhibitors' Activity in Breast Cancer: An Overview.Current topics in medicinal chemistry · 2025
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Fang-Chi HsuThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 110, Taiwan.ORCID 0000-0001-6955-929X
Hsin-Lun LeeDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yin-Ju ChenGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-9516-9463
Yao-An ShenDepartment of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-4393-2794
Yi-Chieh TsaiDepartment of Radiation Oncology, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan.
Meng-Huang WuDepartment of Orthopedics, Taipei Medical University Hospital, Taipei 110, Taiwan.ORCID 0000-0003-1606-2444
Chia-Chun KuoDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan.
Long-Sheng LuDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan.ORCID 0000-0002-4247-1981
Shauh-Der YehDepartment of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wen-Sheng HuangDepartment of Nuclear Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.
Chia-Ning ShenThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 110, Taiwan.ORCID 0000-0002-0747-217X
Jeng-Fong ChiouThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 110, Taiwan.
Taipei Medical University Hospital · TWTaipei Medical University · TWGenomics Research Center, Academia Sinica · TWTaipei Medical University-Shuang Ho Hospital · TW

Funding

Ministry of Science and Technology MOST 108-2314-B-038- 038
6 · The paper itself

Abstract

Magnetic resonance-guided focused ultrasound surgery (MRgFUS) constitutes a noninvasive treatment strategy to ablate deep-seated bone metastases. However, limited evidence suggests that, although cytokines are influenced by thermal necrosis, there is still no cytokine threshold for clinical responses. A prediction model to approximate the postablation immune status on the basis of circulating cytokine activation is thus needed. IL-6 and IP-10, which are proinflammatory cytokines, decreased significantly during the acute phase. Wound-healing cytokines such as VEGF and PDGF increased after ablation, but the increase was not statistically significant. In this phase, IL-6, IL-13, IP-10, and eotaxin expression levels diminished the ongoing inflammatory progression in the treated sites. These cytokine changes also correlated with the response rate of primary tumor control after acute periods. The few-shot learning algorithm was applied to test the correlation between cytokine levels and local control (

Indexed as

bone metastasisHIFUmachine learningmagnetic resonance-guided focused ultrasound surgeryprognosis prediction

Identifiers

PMID35053608
PMCPMC8773927
OpenAlexW4205317213

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.