ArticleCancers2022
Clinical-Pathological and Molecular Evaluation of 451 NIFTP Patients from a Single Referral Center.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinical, ultrasonographic, and cytological characteristics of niftp and postoperative outcomes: a retrospective cohort study.Endocrine · 2026Article
- Predictive factors of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: A single-center study.Turkish journal of surgery · 2026Article
- Non-Invasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTPs).The Kaohsiung journal of medical sciences · 2025Review
- NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS.Endocrine · 2024Article
- A Comprehensive Study on the Diagnosis and Management of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.Thyroid : official journal of the American Thyroid Association · 2023Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundNon-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs) were introduced in thyroid pathology in 2016. NIFTPs are a group of follicular neoplasm with an indolent behaviour. In this study, we gathered a large retrospective cohort of NIFTPs and compared those presenting as solitary lesions and NIFTPs found in multifocal setting.
methodsA retrospective search of NIFTPs was performed, and the clinico-pathological features were recorded. For a subgroup of patients, pre-surgical ultrasound (US) evaluation, cytological diagnosis, and molecular analysis were available.
resultsWe collected 451 NIFTPs; 254 (56.3%) were truly solitary tumours, while 197 coexisted with one or more NIFTP/cancer. Contrasting unifocal and multifocal settings, NIFTPs size was the only significantly different parameter. Preoperatively, NIFTP nodules mostly showed low-risk US characteristics, indeterminate cytology and a RAS-like molecular profile.
conclusionNIFTPs often coexist with collateral thyroid tumours. However, no clinical-pathological differences can be observed between solitary and "multifocal" NIFTPs. Despite the well-established clinical indolence of NIFTP, a careful monitoring of the contralateral lobe should not be excluded.
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