Evidence map›Paper›PMID 35053561›Full record

ArticleCancers2022

Effect of Previous Alkylating Agent Exposure on Follicle Numbers in Cryopreserved Prepubertal and Young Adult Ovarian Tissue after Long-Term Xenografting.

Mirja Nurmio, Babak Asadi-Azarbaijani, Mi Hou, Ronja Kiviö, Jorma Toppari, Helena Tinkanen, Tiina Laine, Irma C Oskam, Kirsi Jahnukainen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Mirja NurmioResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
Babak Asadi-AzarbaijaniFaculty of Health Studies, VID Specialized University, 0319 Oslo, Norway.
Mi HouNORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institute and University Hospital, 17164 Stockholm, Sweden.
Ronja KiviöResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
Jorma ToppariResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
Helena TinkanenDepartment of Obstetrics and Gynecology, Outpatient Department of Infertility Treatment and Gynecological Endocrinology, Tampere University Hospital, 33520 Tampere, Finland.
Tiina LainePediatric Research Center, New Children's Hospital, 00029 Helsinki, Finland.
Irma C OskamThe Livestock Production Research Centre, Norwegian University of Life Sciences, 1432 Ås, Norway.
Kirsi JahnukainenNORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institute and University Hospital, 17164 Stockholm, Sweden.ORCID 0000-0001-9296-2028
University of Turku · FIKarolinska University Hospital · SEHelsinki Children's Hospital · FINorwegian University of Life Sciences · NOTampere University Hospital · FIVID Specialized University · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PURPOSE AND

methodsTo elucidate whether previous cancer treatment affects graft recovery and follicle numbers, morphology, and development in grafts, cryopreserved ovarian biopsies obtained from 18 cancer patients aged 1-24 years with and without exposure to chemotherapy were xenografted as 1 mm

resultsGraft recovery showed no association with chemotherapy exposure, pubertal stage, or leukemia contamination. Total follicle number per recovered graft varied between 0 and 1031 in the chemotherapy-exposed and between 0 and 502 in the non-chemotherapy-exposed group. Atretic follicles formed the largest proportion of the follicle pool in chemotherapy-exposed grafts. Increased atresia correlated with exposure to alkylating agents (mean ± SD 8866.2 ± 9316.3 mg/m

conclusionThe observation confirms the harmful effects of alkylating agents on ovarian tissue. Therapy at the median cumulative dose of 8866 mg/m

Indexed as

alkylating agentschildren and young adultsfertility preservationovarian folliclesxenografting

Identifiers

PMID35053561
PMCPMC8773859
OpenAlexW4206754822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.