Evidence map›Paper›PMID 35053556›Full record

ArticleCancers2022

A Small Molecule-Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Charlotte Kopitz, Melanie Heroult, Dmitry Zubov, Joerg Willuda, Thomas Schlange, Antje Kahnert, Harvey Wong, Raquel Izumi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Ru-Based NSAIDs as Potential Anticancer Therapeutics.Molecules (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Optimizing the enzymatic release of MMAE fromFrontiers in pharmacology · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hans-Georg LerchenVincerx Pharma GmbH, 40789 Monheim am Rhein, Germany.ORCID 0000-0001-8746-9554
Beatrix Stelte-LudwigVincerx Pharma GmbH, 40789 Monheim am Rhein, Germany.ORCID 0000-0002-1045-1134
Charlotte KopitzNuvisan Innovation Campus, 13353 Berlin, Germany.
Melanie HeroultCrop Science Division, Bayer AG, 65926 Frankfurt am Main, Germany.
Dmitry ZubovPharmaceuticals R&D, Bayer AG, 42096 Wuppertal, Germany.
Joerg WilludaPharmaceuticals R&D, Bayer AG, 13353 Berlin, Germany.
Thomas SchlangePharmaceuticals R&D, Bayer AG, 42096 Wuppertal, Germany.
Antje KahnertPharmaceuticals R&D, Bayer AG, 42096 Wuppertal, Germany.
Harvey WongVincerx Pharma Inc., Palo Alto, CA 94306, USA.
Raquel IzumiVincerx Pharma Inc., Palo Alto, CA 94306, USA.
Ahmed HamdyVincerx Pharma Inc., Palo Alto, CA 94306, USA.
Bayer (Germany) · DENuvisan (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To improve tumor selectivity of cytotoxic agents, we designed VIP236, a small molecule-drug conjugate consisting of an α

Indexed as

camptothecin payloadneutrophil elastasesmall molecule–drug conjugateSMDCSN38 derivativetopoisomerase 1tumor microenvironmentVIP126VIP236αVβ3 integrin

Identifiers

PMID35053556
PMCPMC8773721
OpenAlexW4206583229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.