Evidence map›Paper›PMID 35053517›Full record

ArticleCancers2022

Therapeutic Challenges in Patients with Gynecologic Carcinosarcomas: Analysis of a Multicenter National Cohort Study from the French Prospective TMRG Network.

Clémence Romeo, Olivia Le Saux, Margaux Jacobs, Florence Joly, Gwenael Ferron, Laure Favier, Jean-David Fumet, Nicolas Isambert, Pierre-Emmanuel Colombo, Renaud Sabatier and 15 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Frontiers of Ovarian Carcinosarcoma.Current treatment options in oncology · 2023
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 14 institutions in 1 country.

Clémence RomeoMedical Oncology Department, Centre Léon Bérard, 69008 Lyon, France.ORCID 0000-0003-1280-8069
Olivia Le SauxCancer Research Center of Lyon CRCL, UMR Inserm 1052, CNRS 5286, Centre Léon Bérard, 69008 Lyon, France.
Margaux JacobsMedical Oncology Department, Centre François Baclesse, 14000 Caen, France.
Florence JolyMedical Oncology Department, Centre François Baclesse, 14000 Caen, France.
Gwenael FerronGINECO Group, 75008 Paris, France.
Laure FavierGINECO Group, 75008 Paris, France.
Jean-David FumetMedical Oncology Department, Centre Georges François Leclerc, 21000 Dijon, France.
Nicolas IsambertGINECO Group, 75008 Paris, France.
Pierre-Emmanuel ColomboGINECO Group, 75008 Paris, France.ORCID 0000-0002-0697-109X
Renaud SabatierGINECO Group, 75008 Paris, France.ORCID 0000-0002-5821-682X
Ludovic BastideMedical Oncology Department, Institut Paoli Calmettes, 13009 Marseille, France.
Amandine CharretonMedical Oncology Department, Centre Léon Bérard, 69008 Lyon, France.
Mojgan Devouassoux-ShisheboranGINECO Group, 75008 Paris, France.
Witold GertychGynaecologic Surgery Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Lyon, France.ORCID 0000-0003-1233-5003
Coraline DubotGINECO Group, 75008 Paris, France.ORCID 0000-0002-9761-0395
Diana Bello RoufaiMedical Oncology Department, Institut Curie, Saint-Cloud, 92210 Paris, France.ORCID 0000-0002-2817-7866
Guillaume BataillonGINECO Group, 75008 Paris, France.
Dominique BertonGINECO Group, 75008 Paris, France.
Elsa KalbacherGINECO Group, 75008 Paris, France.
Patricia PautierGINECO Group, 75008 Paris, France.
Christophe PomelGINECO Group, 75008 Paris, France.
Caroline CornouSurgical Oncology Department, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
Isabelle TreilleuxGINECO Group, 75008 Paris, France.
Audrey Lardy-CleaudBiostatistic Department, DRCI, Centre Léon Bérard, 69008 Lyon, France.
Isabelle Ray-CoquardMedical Oncology Department, Centre Léon Bérard, 69008 Lyon, France.ORCID 0000-0003-2472-8306
Centre Léon Bérard · FRArcagy Gineco · FRCentre Georges François Leclerc · FRCentre François Baclesse · FRCentre Jean Perrin · FRHospices Civils de Lyon · FRInstitut Pprime · FRCentre Hospitalier Universitaire de Besançon · FRCentre National de la Recherche Scientifique · FRInstitut Claudius Regaud · FRInstitut Curie · FRInstitut de Cancérologie de l'Ouest · FRInstitut Gustave Roussy · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGynecological carcinosarcomas are rare and aggressive diseases, with a poor prognosis. The rarity of these tumors explains the lack of robust and specific data available in the literature. The objective of this study was to investigate the impact of initial adjuvant treatment and recurrent therapeutic strategies. PATIENTS AND

methodsA multicentric cohort study within the French national prospective Rare Malignant Gynecological Tumors (TMRG) network was conducted. Data from all included carcinosarcomas diagnosed between 2011 and 2018 were retrospectively collected.

results425 cases of uterine and ovarian carcinosarcomas (

conclusionsInterestingly, this vast prospective cohort of gynecological carcinosarcoma patients from the French national Rare Malignant Gynecological Tumors network (i) highlights the positive impact of adjuvant CT on survival in all localized stages (including FIGO IA uterine carcinosarcomas), (ii) confirms the importance of platinum-based combination as an option for relapse setting, and (iii) reports median PFS for various therapeutic strategies in the relapse setting.

Indexed as

adjuvant treatmentchemotherapycytotoxic agentovarian carcinosarcomarare cancerTMRG networkuterine carcinosarcoma

Identifiers

PMID35053517
PMCPMC8773830
OpenAlexW4206294557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.