Evidence map›Paper›PMID 35053451›Full record

ArticleCancers2022

Toward Tumor Fight and Tumor Microenvironment Remodeling: PBA Induces Cell Cycle Arrest and Reduces Tumor Hybrid Cells' Pluripotency in Bladder Cancer.

Carolina Rubio, José Avendaño-Ortiz, Raquel Ruiz-Palomares, Viktoriya Karaivanova, Omaira Alberquilla, Rebeca Sánchez-Domínguez, José Carlos Casalvilla-Dueñas, Karla Montalbán-Hernández, Iris Lodewijk, Marta Rodríguez-Izquierdo and 15 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review of BCG immunotherapy for bladder cancer.Clinical microbiology reviews · 2025
    Review
  3. Article
  4. Cell Fusion and Syncytia Formation in Cancer.Results and problems in cell differentiation · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 3 countries.

Carolina RubioBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0003-0098-2297
José Avendaño-OrtizTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.ORCID 0000-0003-2774-1821
Raquel Ruiz-PalomaresBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Viktoriya KaraivanovaMolecular Oncology Unit, CIEMAT (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas), Avenida Complutense nº40, 28040 Madrid, Spain.
Omaira AlberquillaDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), 28029 Madrid, Spain.
Rebeca Sánchez-DomínguezDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), 28029 Madrid, Spain.
José Carlos Casalvilla-DueñasTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
Karla Montalbán-HernándezTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
Iris LodewijkBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0002-5208-8249
Marta Rodríguez-IzquierdoUro-Oncology Unit, 12 de Octubre University Hospital, Av Córdoba s/n, 28041 Madrid, Spain.
Ester Munera-MaravillaBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Sandra P NunesBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0003-4466-037X
Cristian Suárez-CabreraBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Miriam Pérez-CrespoBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Víctor G MartínezBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0002-5515-0626
Lucía MoralesBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Mercedes Pérez-EscavyBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Miguel Alonso-SánchezBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.
Roberto Lozano-RodríguezTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.ORCID 0000-0003-0093-9707
Francisco J CuetoTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
Luis A AguirreTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.ORCID 0000-0003-0903-9385
Félix Guerrero-RamosUro-Oncology Unit, 12 de Octubre University Hospital, Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0002-0767-3465
Jesús M ParamioBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0001-7520-3177
Eduardo López-CollazoTumorImmunology Laboratory and Innate Immunity Group, Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
Marta DueñasBiomedical Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0003-0857-9726
Research Institute Hospital 12 de Octubre · ESHospital La Paz Institute for Health Research · ESCentre for Biomedical Network Research on Rare Diseases · ESCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESCentro de Investigaciones Energéticas, Medioambientales y Tecnológicas · ES

Funding

Asociación Española Contra el Cáncer POSTD19036MORAAsociación Española Contra el Cáncer PRDMA19024LODECentro de Investigación Biomédica en Red de Cáncer CB16/12/00228Fundação para a Ciência e Tecnologia SFRH/BD/ 144241/2019Fundación Familia Alonso ELCInstituto de Salud Carlos III PI20/00813
6 · The paper itself

Abstract

Bladder cancer (BC) is the second most frequent cancer of the genitourinary system. The most successful therapy since the 1970s has consisted of intravesical instillations of

Indexed as

bladder cancerHDACitumor hybrid cellstumor microenvironment

Identifiers

PMID35053451
PMCPMC8773853
OpenAlexW4205142219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.