Evidence map›Paper›PMID 35053416›Full record

ArticleCells2022

STAT3 Is the Master Regulator for the Forming of 3D Spheroids of 3T3-L1 Preadipocytes.

Hiroshi Ohguro, Yosuke Ida, Fumihito Hikage, Araya Umetsu, Hanae Ichioka, Megumi Watanabe, Masato Furuhashi

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hiroshi OhguroDepartments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Yosuke IdaDepartments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.ORCID 0000-0002-5165-6507
Fumihito HikageDepartments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.ORCID 0000-0002-0124-5494
Araya UmetsuDepartments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Hanae IchiokaDepartments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Megumi WatanabeDepartments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.ORCID 0000-0002-8026-6532
Masato FuruhashiDepartments of Cardiovascular, Renal and Metabolic Medicine, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.ORCID 0000-0002-0145-3541
Sapporo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To elucidate the currently unknown mechanisms responsible for the diverse biological aspects between two-dimensional (2D) and three-dimensional (3D) cultured 3T3-L1 preadipocytes, RNA-sequencing analyses were performed. During a 7-day culture period, 2D- and 3D-cultured 3T3-L1 cells were subjected to lipid staining by BODIPY, qPCR for adipogenesis related genes, including

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAnimalsGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksMiceRNA, MessengerSignal TransductionSpheroids, CellularSTAT3 Transcription FactorRNA, MessengerSTAT3 Transcription Factor3D spheroid culture3T3-L1 preadipocyteGene Ontology (GO) enrichment analysisIngenuity Pathway Analysis (IPA)RNA sequencing

Identifiers

PMID35053416
PMCPMC8774605
OpenAlexW4205928324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.