Evidence map›Paper›PMID 35053406›Full record

ArticleCells2022

The Electrostatic Basis of Diacylglycerol Pyrophosphate-Protein Interaction.

Zachary Graber, Desmond Owusu Kwarteng, Shannon M Lange, Yannis Koukanas, Hady Khalifa, Jean W Mutambuze, Edgar E Kooijman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zachary GraberDepartment of Chemistry & Biochemistry, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.
Desmond Owusu KwartengDepartment of Biological Sciences, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.ORCID 0000-0003-3735-1093
Shannon M LangeDepartment of Biological Sciences, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.
Yannis KoukanasDepartment of Biological Sciences, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.
Hady KhalifaDepartment of Biological Sciences, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.
Jean W MutambuzeDepartment of Biological Sciences, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.
Edgar E KooijmanDepartment of Biological Sciences, Kent State University, 800 E. Summit St., Kent, OH 44242, USA.ORCID 0000-0002-1030-437X
Kent State University · USMount Vernon Nazarene University · US

Funding

National Science Foundation CHE-1412920
6 · The paper itself

Abstract

Diacylglycerol pyrophosphate (DGPP) is an anionic phospholipid formed in plants, yeast, and parasites under multiple stress stimuli. It is synthesized by the phosphorylation action of phosphatidic acid (PA) kinase on phosphatidic acid, a signaling lipid with multifunctional properties. PA functions in the membrane through the interaction of its negatively charged phosphomonoester headgroup with positively charged proteins and ions. DGPP, like PA, can interact electrostatically via the electrostatic-hydrogen bond switch mechanism but differs from PA in its overall charge and shape. The formation of DGPP from PA alters the physicochemical properties as well as the structural dynamics of the membrane. This potentially impacts the molecular and ionic binding of cationic proteins and ions with the DGPP enriched membrane. However, the results of these important interactions in the stress response and in DGPP's overall intracellular function is unknown. Here, using

Indexed as

Static ElectricityCations, DivalentDiphosphatesGlycerolLysineMagnetic Resonance SpectroscopyModels, MolecularPeptidesPhosphatidylcholinesProteins1,2-oleoylphosphatidylcholineCations, Divalentdiacylglycerol pyrophosphateDiphosphatesGlycerolLysinePeptidesPhosphatidylcholinesProteinslipid physical chemistrymembrane electrostaticsprotein-lipid interactions

Identifiers

PMID35053406
PMCPMC8774204
OpenAlexW4205117902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.