Evidence map›Paper›PMID 35053396›Full record

ArticleCells2022

Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss.

Prameet Kaur, Ellora Hui Zhen Chua, Wen Kin Lim, Jiarui Liu, Nathan Harmston, Nicholas S Tolwinski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Using Optogenetics to Model Cellular Effects of Alzheimer's Disease.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Prameet KaurDivision of Science, Yale-NUS College, Singapore 138527, Singapore.
Ellora Hui Zhen ChuaDivision of Science, Yale-NUS College, Singapore 138527, Singapore.ORCID 0000-0002-5520-2254
Wen Kin LimDivision of Science, Yale-NUS College, Singapore 138527, Singapore.ORCID 0000-0002-4762-131X
Jiarui LiuDivision of Science, Yale-NUS College, Singapore 138527, Singapore.
Nathan HarmstonDivision of Science, Yale-NUS College, Singapore 138527, Singapore.ORCID 0000-0002-8589-2938
Nicholas S TolwinskiDivision of Science, Yale-NUS College, Singapore 138527, Singapore.ORCID 0000-0002-8507-2737
Yale-NUS College · SG

Funding

Ministry of Education IG19-SI102
6 · The paper itself

Abstract

Patients with Alzheimer's disease suffer from a decrease in brain mass and a prevalence of amyloid-β plaques. These plaques are thought to play a role in disease progression, but their exact role is not entirely established. We developed an optogenetic model to induce amyloid-β intracellular oligomerization to model distinct disease etiologies. Here, we examine the effect of Wnt signaling on amyloid in an optogenetic,

Indexed as

Wnt Signaling PathwayAmyloid beta-PeptidesAnimalsDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianGene Expression RegulationIntestinesLongevityOptogeneticsStem CellsAmyloid beta-PeptidesDrosophila ProteinsAlzheimer’s diseaseamyloid-βDrosophilaWnt

Identifiers

PMID35053396
PMCPMC8774390
OpenAlexW4206221094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.