Evidence map›Paper›PMID 35053381›Full record

ArticleCells2022

Revisiting the Non-Coding Nature of Pospiviroids.

Konstantina Katsarou, Charith Raj Adkar-Purushothama, Emilios Tassios, Martina Samiotaki, Christos Andronis, Purificación Lisón, Christoforos Nikolaou, Jean-Pierre Perreault, Kriton Kalantidis

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. First Detection of Potato Spindle Tuber Viroid in Natural Isolates of Potato Blight Agent Phytophthora infestans.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023
    Article
  8. Analysis of Hop Stunt Viroid Diversity in Grapevine (Pathogens (Basel, Switzerland) · 2023
    Article
  9. PSTVd infection inFrontiers in plant science · 2023
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Konstantina KatsarouDepartment of Biology, University of Crete, Vassilika Vouton, 71409 Heraklion, Greece.ORCID 0000-0003-2728-443X
Charith Raj Adkar-PurushothamaRNA Group/Groupe ARN, Département de Biochimie, Faculté de Médecine des Sciences de la Santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.ORCID 0000-0001-8868-6008
Emilios TassiosDepartment of Biology, University of Crete, Vassilika Vouton, 71409 Heraklion, Greece.
Martina SamiotakiBiomedical Sciences Research Center "Alexander Fleming", Institute for Bioinnovation, 16672 Vari, Greece.
Christos AndronisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, 71110 Heraklion, Greece.ORCID 0000-0002-6174-579X
Purificación LisónInstituto de Biología Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Científicas (CSIC), Universitat Politècnica de València (UPV), Ciudad Politécnica de la Innovación (CPI) 8 E, Ingeniero Fausto Elio s/n, 46011 Valencia, Spain.ORCID 0000-0002-1662-8084
Christoforos NikolaouDepartment of Biology, University of Crete, Vassilika Vouton, 71409 Heraklion, Greece.ORCID 0000-0003-3001-6786
Jean-Pierre PerreaultRNA Group/Groupe ARN, Département de Biochimie, Faculté de Médecine des Sciences de la Santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.
Kriton KalantidisDepartment of Biology, University of Crete, Vassilika Vouton, 71409 Heraklion, Greece.
University of Crete · GRUniversité de Sherbrooke · CAAlexander Fleming Biomedical Sciences Research Center · GRConsejo Superior de Investigaciones Científicas · ESFoundation for Research and Technology Hellas · GR

Funding

Development of national research network to 'Grape' of the national scale of the public investments program of the GSRT. 2018ΣE01300000Emblematic Action for Research in the Cretan Agrofood sector: Four Institutions, Four References'-AGRO4Crete 2018ΣΕ01300000Grant from the Université de Sherbrooke 0Natural Sciences and Engineering Research Council of Canada 155219-17The Greek Research Infrastructure for Personalized Medicine (pMED-GR)" which is implemented under the Action "Reinforcement of the Research and Innovation Infrastructure", funded by the Operational Program "Competitiveness, Entrepreneurship and Innovatio MIS 5002802
6 · The paper itself

Abstract

Viroids are small, circular, highly structured pathogens that infect a broad range of plants, causing economic losses. Since their discovery in the 1970s, they have been considered as non-coding pathogens. In the last few years, the discovery of other RNA entities, similar in terms of size and structure, that were shown to be translated (e.g., cirRNAs, precursors of miRNA, RNA satellites) as well as studies showing that some viroids are located in ribosomes, have reignited the idea that viroids may be translated. In this study, we used advanced bioinformatic analysis, in vitro experiments and LC-MS/MS to search for small viroid peptides of the PSTVd. Our results suggest that in our experimental conditions, even though the circular form of PSTVd is found in ribosomes, no produced peptides were identified. This indicates that the presence of PSTVd in ribosomes is most probably not related to peptide production but rather to another unknown function that requires further study.

Indexed as

Base SequenceMass SpectrometryNicotianaOpen Reading FramesPeptidesPolyribosomesProtein BiosynthesisRibosomesRNA, CircularRNA, UntranslatedSolanum lycopersicumViroidsPeptidesRNA, CircularRNA, UntranslatedcirRNAmass spectrometrynon-coding RNAPSTVdtranslationviroid

Identifiers

PMID35053381
PMCPMC8773695
OpenAlexW4205102420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.