Evidence map›Paper›PMID 35053375›Full record

ArticleCells2022

Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer.

Madhuchhanda Kundu, Sumita Raha, Avik Roy, Kalipada Pahan

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Madhuchhanda KunduDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.
Sumita RahaDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0001-6480-7266
Avik RoyDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.
Kalipada PahanDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.
Rush University Medical Center · US

Funding

Muscle building supplement HMB for remyelinationR01AT010980 · NCCIH · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2020 to 2024
$2.7M
NIH HHS AT10980
6 · The paper itself

Abstract

Although some therapies are available for regular breast cancers, there are very few options for triple-negative breast cancer (TNBC). Here, we demonstrated that serum level of IL-12p40 monomer (p40) was much higher in breast cancer patients than healthy controls. On the other hand, levels of IL-12, IL-23 and p40 homodimer (p40

Indexed as

Xenograft Model Antitumor AssaysAdaptive ImmunityAnimalsAntibodies, MonoclonalCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansImmunotherapyInterferon-gammaInterleukin-12Interleukin-12 Subunit p40Interleukin-23MacrophagesMiceMice, Inbred NODAntibodies, MonoclonalInterferon-gammaInterleukin-12Interleukin-12 Subunit p40Interleukin-23IL-12p40 monomerimmunotherapypatient-derived xenograft mouse modeltriple-negative breast cancertumor-associated macrophage

Identifiers

PMID35053375
PMCPMC8773899
OpenAlexW4205120116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.