ReviewCells2022
Sex Hormones, Growth Hormone, and the Cornea.
Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 62 citations in OpenAlex.
- Infectious bacterial keratitis management in a Swedish region: Risk factors, treatment and time-to-resolution.Acta ophthalmologica · 2026Article
- Comparison of the visual and optical outcomes after different corneal refractive surgeries for asymmetric corneal astigmatism.International ophthalmology · 2026Article
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- Machine learning-based transcriptomic analysis of differentially expressed genes in the epithelium and stroma of keratoconus.Human genomics · 2026Article
- Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model.Investigative ophthalmology & visual science · 2026Article
- Association between refractive status and quantitative corneal subbasal nerve plexus parameters in young adults.BMC ophthalmology · 2026Article
- Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for At-Risk Populations.Ophthalmology science · 2026Review
- The Impact of Aging and Sex on Corneal Nerve Density and Function.Investigative ophthalmology & visual science · 2026Article
- Sex hormone-mediated corneal remodeling in keratoconus: a multivariate analysis of tomographic and biomechanical variations across gender, age, and menstrual phases.BMC ophthalmology · 2026Article
- In Vivo Biomechanical Characteristics of Human Corneas With Phase-Decorrelation OCT.Investigative ophthalmology & visual science · 2026Article
- Rapid Pterygium Progression in a Child on Growth Hormone Therapy: A Case Report and Literature Review.Cureus · 2026Article
- A TabPFN-based prediction system for refractive error and dry eye comorbidity: a retrospective study using large-scale real-world data.Frontiers in cell and developmental biology · 2026Article
- Effects of age and sex on the early visual outcomes of small-incision lenticule extraction for myopia correction.BMC ophthalmology · 2025Article
- The Impact of Sex Hormones on Keratoconus.Journal of clinical medicine · 2025Review
- Chronic intermittent hypoxia modulates corneal fibrotic markers and inflammatory cytokine expression in a sex-dependent manner.Experimental eye research · 2025Article
- Ultrasound-Assisted Microcontinuous Process Facilitates the Selective Deuteration of Steroid Hormones.Journal of labelled compounds & radiopharmaceuticals · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Association Between Maternal Pre-Pregnancy Body Mass Index and Astigmatism and Corneal Curvature in Offspring: A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Effect of Age and Gender on Corneal Epithelial Thickness in Refractive Surgery Candidates.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Clinical features, risk factors and outcomes of contact lens-related bacterial keratitis in Nottingham, UK: a 7-year study.Eye (London, England) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The growth and maintenance of nearly every tissue in the body is influenced by systemic hormones during embryonic development through puberty and into adulthood. Of the ~130 different hormones expressed in the human body, steroid hormones and peptide hormones are highly abundant in circulation and are known to regulate anabolic processes and wound healing in a tissue-dependent manner. Of interest, differential levels of sex hormones have been associated with ocular pathologies, including dry eye disease and keratoconus. In this review, we discuss key studies that have revealed a role for androgens and estrogens in the cornea with focus on ocular surface homeostasis, wound healing, and stromal thickness. We also review studies of human growth hormone and insulin growth factor-1 in influencing ocular growth and epithelial regeneration. While it is unclear if endogenous hormones contribute to differential corneal wound healing in common animal models, the abundance of evidence suggests that systemic hormone levels, as a function of age, should be considered as an experimental variable in studies of corneal health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.