Evidence map›Paper›PMID 35053271›Full record

ArticleBiomolecules2022

The Molecular Mechanism of Human Voltage-Dependent Anion Channel 1 Blockade by the Metallofullerenol Gd@C

Xiuxiu Wang, Nan Yang, Juan Su, Chenchen Wu, Shengtang Liu, Lei Chang, Leigh D Plant, Xuanyu Meng

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiuxiu WangState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Nan YangState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Juan SuState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Chenchen WuState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Shengtang LiuState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Lei ChangState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.ORCID 0000-0002-2288-1748
Leigh D PlantDepartment of Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-1622-1655
Xuanyu MengState Key Laboratory of Radiation Medicine and Protection, Institute of Quantitative Biology and Medicine, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.ORCID 0000-0003-1644-6552
Soochow University · CNNortheastern University · US

Funding

SUMO-regulation of ion channels via PIP2R01HL144615 · NHLBI · NORTHEASTERN UNIVERSITY · PI PLANT, LEIGH DANIEL · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL144615
6 · The paper itself

Abstract

The endohedral metallofullerenol Gd@C

Indexed as

Antineoplastic AgentsFullerenesNeoplasmsOrganometallic CompoundsVoltage-Dependent Anion Channel 1GadoliniumHumansAntineoplastic AgentsFullerenesGadoliniumOrganometallic CompoundsVDAC1 protein, humanVoltage-Dependent Anion Channel 1Gd-fullerenolmolecular dynamics simulationsnanodrugPMFVDAC1

Identifiers

PMID35053271
PMCPMC8773804
OpenAlexW4205786379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.