ReviewBiomolecules2021
A Comprehensive Review on the Heavy Metal Toxicity and Sequestration in Plants.
Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 308 citations in OpenAlex.
- Emerging role of osmoprotectant glycine betaine to mitigate heavy metals toxicity in plants: a systematic review.Biologia futura · 2024Pooled it
- Lead Management in Perovskite Photovoltaics: Status and Perspectives.ChemSusChem · 2026Review
- Article
- Metal-dependent inhibition of germination and seedling growth in two onion cultivars under in vitro conditions.Scientific reports · 2026Article
- Non-coding RNAs as central regulators of phytohormone signaling in plant abiotic stress responses.Plant molecular biology · 2026Review
- Reactive Oxygen Species in Crop Plants: Production, Detoxification, Signaling, and Molecular Cross-Talk.Plants (Basel, Switzerland) · 2026Review
- Harnessing biostimulants to alleviate potentially toxic element stress in vegetable crops.Planta · 2026Review
- Smart nanoparticle vaccines integrate nanotechnology artificial intelligence and immunoengineering for precision immunization.Discover nano · 2026Review
- Review
- Astaxanthin biofortification enhances tobacco tolerance to lead stress through boosting antioxidant defense, reducing Pb accumulation, and modulating detoxification pathways.Journal of advanced research · 2026Article
- Chloroplast: structural and functional alteration under nickel stress and tolerance mechanism via the omics approach.Plant cell reports · 2026Review
- Polyploidy and zinc nanoparticles enhanced cadmium tolerance by regulating antioxidants and transport proteins.Plant cell reports · 2026Article
- Dopamine modulates antioxidant and phenolic responses to alleviate nickel stress in Salvia officinalis.BMC plant biology · 2026Article
- EDDS-Enhanced Phytoremediation of Cd-Zn Co-Contaminated Soil byPlants (Basel, Switzerland) · 2026Article
- Effects of Toxic Concentrations of Cadmium, Lead, or Zinc on Leaf Morphology, Anatomy and Calcium Oxalate Content in Metallicolous and Non-Metallicolous Ecotypes ofPlants (Basel, Switzerland) · 2026Article
- Article
- Article
- Co-application of selenium nanoparticles andFrontiers in plant science · 2026Article
- Heavy Metal Toxicity in Cereals: Uptake Mechanisms, Physiological Impacts, and Mitigation Strategies.Toxics · 2025Review
- Ameliorative effects of strigolactone on tolerance to lead stress on lettuce (Lactuca sativa L.) plants.Scientific reports · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metal (HM) toxicity has become a global concern in recent years and is imposing a severe threat to the environment and human health. In the case of plants, a higher concentration of HMs, above a threshold, adversely affects cellular metabolism because of the generation of reactive oxygen species (ROS) which target the key biological molecules. Moreover, some of the HMs such as mercury and arsenic, among others, can directly alter the protein/enzyme activities by targeting their -SH group to further impede the cellular metabolism. Particularly, inhibition of photosynthesis has been reported under HM toxicity because HMs trigger the degradation of chlorophyll molecules by enhancing the chlorophyllase activity and by replacing the central Mg ion in the porphyrin ring which affects overall plant growth and yield. Consequently, plants utilize various strategies to mitigate the negative impact of HM toxicity by limiting the uptake of these HMs and their sequestration into the vacuoles with the help of various molecules including proteins such as phytochelatins, metallothionein, compatible solutes, and secondary metabolites. In this comprehensive review, we provided insights towards a wider aspect of HM toxicity, ranging from their negative impact on plant growth to the mechanisms employed by the plants to alleviate the HM toxicity and presented the molecular mechanism of HMs toxicity and sequestration in plants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.