Evidence map›Paper›PMID 35053153›Full record

ArticleBiomolecules2021

Dysregulation of DNA Methylation and Epigenetic Clocks in Prostate Cancer among Puerto Rican Men.

Anders Berglund, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Raymond Linares, Joshua Marcial, Caren Abreu-Takemura, Natasha Moreno, Ryan Putney and 10 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Anders BerglundDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-0393-3530
Jaime MattaDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.ORCID 0000-0001-6668-9021
Jarline Encarnación-MedinaDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.ORCID 0000-0002-0354-6274
Carmen Ortiz-SanchézDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.ORCID 0000-0003-3567-7866
Julie DutilDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Raymond LinaresDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Joshua MarcialDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Caren Abreu-TakemuraDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Natasha MorenoDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Ryan PutneyDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Ratna ChakrabartiBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA.ORCID 0000-0002-0261-8520
Hui-Yi LinBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Kosj YamoahDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Carlos Diaz OstermanDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Liang WangDepartment of Molecular Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-9364-8572
Jasreman DhillonDepartment of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Youngchul KimDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Seung Joon KimDepartment of Internal Medicine, Catholic University of Korea, Seoul 06591, Korea.
Gilberto Ruiz-DeyaDepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce 00716-2347, Puerto Rico.
Jong Y ParkDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-6384-6447
Ponce Health Sciences University · PRMoffitt Cancer Center · USCatholic University of Korea · KRLouisiana State University Health Sciences Center New Orleans · USUniversity of Central Florida · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KENNETH Lynn WRIGHT · 2012 to 2026
$23.1M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Harold I Saavedra · 2012 to 2026
$23.0M
NCI NIH HHS P30 CA076292NCI NIH HHS U54 CA163068NCI NIH HHS U54 CA163071
6 · The paper itself

Abstract

In 2021, approximately 248,530 new prostate cancer (PCa) cases are estimated in the United States. Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US. The objective of this study was to assess DNA methylation patterns between aggressive and indolent PCa along with ancestry proportions in 49 H/L men from Puerto Rico (PR). Prostate tumors were classified as aggressive (

Indexed as

Biological ClocksDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticAgedCpG IslandsDNA, NeoplasmHumansMaleMiddle AgedPilot ProjectsProstatic NeoplasmsDNA, Neoplasmaggressivenessancestry structureDNA methylationHispanic/Latino populationprostate cancer

Identifiers

PMID35053153
PMCPMC8773891
OpenAlexW4200221056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.