ArticleAntibiotics (Basel, Switzerland)2022
The Overlooked Issue of Outpatient Combination Antibiotic Prescribing in Low- and Middle-Income Countries: An Example from Syria.
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of antibiotics prescription amongst patients with and without COVID-19 in low- and middle-income countries: a systematic review and meta-analysis.Pathogens and global health · 2023Pooled it
- Population-Level Uncoupling of Antimicrobial Usage and Resistance in Community-OnsetPathogens (Basel, Switzerland) · 2026Article
- Exploring antibiotic knowledge and practices in a sample of damascus residents: a foundation for informed interventions and public health strategies.BMC public health · 2026Article
- Syria's intersecting crises exacerbate antimicrobial resistance.npj antimicrobials and resistance · 2025Article
- The role of community pharmacists with Syrian migration background in addressing healthcare needs of migrant population in Germany: a qualitative study.BMC health services research · 2025Article
- Antibiotic prescribing in public primary healthcare centres in Maseru, Lesotho.Southern African journal of infectious diseases · 2025Article
- Access to medicines among asylum seekers, refugees and undocumented migrants across the migratory cycle in Europe: a scoping review.BMJ global health · 2024Article
- Development and application of a nomogram model for the prediction of carbapenem-resistantMicrobiology spectrum · 2024Article
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Abstract
This study aimed to determine and describe the prevalence of combination antibiotics dispensed in outpatients with health insurance in Syria. Data on all dispensed medicines between June 2018 and May 2019 for 81,314 adults were obtained, and medicines belonging to the J01 group of the World Health Organization (WHO) anatomical therapeutic classification (ATC) were included in the analysis. Prescriptions were stratified according to the number of antibiotics, age, and sex. Antibiotic utilization was expressed as the number of prescriptions per 1000 persons per year. Out of 59,404 prescriptions for antibiotics, 14.98% contained antibiotic combinations, distributed to 22.49% of the patients. The prevalence of dispensing antibiotic combinations was higher in female patients (23.00%), and the youngest (18-30 years, 26.19%) and oldest age groups (>70 years, 25.19%). The antibiotics most commonly combined were co-amoxiclav, second- and third-generation cephalosporins, and macrolides. Over 60% of the combinations contained ceftriaxone alone or in combination with sulbactam. The present study shows an alarmingly widespread prescription of antibiotic combinations, posing a risk to global health by promoting resistance development.
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