Evidence map›Paper›PMID 35052935›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Biocompatibility and Comfort during Extended Wear of Mel4 Peptide-Coated Antimicrobial Contact Lenses.

Parthasarathi Kalaiselvan, Debarun Dutta, Nagaraju Konda, Pravin Krishna Vaddavalli, Savitri Sharma, Fiona Stapleton, Mark D P Willcox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Antimicrobial activity of a short guanidine mimic immobilised on contact lenses.Journal of materials science. Materials in medicine · 2026
    Article
  5. Ocular Surface Infection and Antimicrobials.Antibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Parthasarathi KalaiselvanSchool of Optometry and Vision Science, UNSW Sydney, Sydney, NSW 2041, Australia.
Debarun DuttaSchool of Optometry and Vision Science, UNSW Sydney, Sydney, NSW 2041, Australia.ORCID 0000-0002-2204-5272
Nagaraju KondaSchool of Medical Sciences, University of Hyderabad, Hyderabad 500 046, India.
Pravin Krishna VaddavalliBausch & Lomb Contact Lens Centre, L V Prasad Eye Institute, Hyderabad 500 034, India.
Savitri SharmaJhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad 500 034, India.ORCID 0000-0001-9979-264X
Fiona StapletonSchool of Optometry and Vision Science, UNSW Sydney, Sydney, NSW 2041, Australia.
Mark D P WillcoxSchool of Optometry and Vision Science, UNSW Sydney, Sydney, NSW 2041, Australia.ORCID 0000-0003-3842-7563

Funding

National Health and Medical Research Council APP1076206
6 · The paper itself

Abstract

(1) Purpose: This study aimed to investigate the effects of Mel4 antimicrobial contact lenses (MACL) on the ocular surface and comfort during extended wear. (2) Methods: A prospective, randomised, double-masked, contralateral clinical trial was conducted with 176 subjects to evaluate the biocompatibility of contralateral wear of MACL. The wearing modality was 14-day extended lens wear for three months. The participants were assessed at lens dispensing, after one night, two weeks, one month and three months of extended wear and one month after study completion. (3) Results: There were no significant differences (

Indexed as

antimicrobial contact lensbiocompatibilityclinical trailcomfortextended wearMel4 peptide

Identifiers

PMID35052935
PMCPMC8772808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.