ReviewAntibiotics (Basel, Switzerland)2021
Antimicrobial Activity of Polyphenols and Natural Polyphenolic Extracts on Clinical Isolates.
Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 3 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- Efficacy of botanical antifungal and conventional antifungal in the treatment of oral candidiasis: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Biological Mechanisms of Polyphenols againstInfectious disorders drug targets · 2025Pooled it
- Pooled it
- Integrated Molecular Docking and Molecular Dynamics Approaches Reveal Potential Antimicrobial Metabolites from Echinoderms,Biology · 2026Article
- Review
- Phytochemicals fromFoods (Basel, Switzerland) · 2026Article
- Natural Antimicrobials from Plants Used as Food Preservatives.Foods (Basel, Switzerland) · 2026Review
- A Multi-Target Phytotherapeutic Approach to Benign Prostatic Hyperplasia: Preclinical Characterization of a PhytoBPH-Mix.Nutrients · 2026Article
- Linking Metabolomic Diversity to Pharmacological Potency in Anonidium mannii Leaf Extracts.Chemistry & biodiversity · 2026Article
- Polyphenols from Byproducts: Their Applications and Health Effects.Antioxidants (Basel, Switzerland) · 2026Review
- Synergistic inhibition of agr quorum sensing in methicillin-resistantMicrobiology spectrum · 2026Article
- BiombalanceAntioxidants (Basel, Switzerland) · 2025Article
- Evaluation of the Quantitative and Structural Antimicrobial Activity of Thymol, Terpinen-4-ol, Citral, and E-2-Dodecenal, Antibiotic Molecules Derived from Essential Oils.Antibiotics (Basel, Switzerland) · 2025Article
- Determination of Bioactive Compounds, Antioxidant Capacity, Safety Assessment, and Antimicrobial Effect ofMolecules (Basel, Switzerland) · 2025Article
- Investigating the biological activities of Sapindus mukorossi seed hydrosol and its potential as a skincare ingredient.Scientific reports · 2025Article
- Assessment of the Antimicrobial Activity ofInternational journal of molecular sciences · 2025Article
- Gemmotherapy Extracts Like the Dog Rose, Lingonberry, Sea Buckthorn, Blackthorn, Common Grape, Hawthorn, Raspberry and Boxwood Feature Variable Yet Excelling Antimicrobial Effects.Antibiotics (Basel, Switzerland) · 2025Article
- Pharmacokinetic Profile of Extracts from the Chayote (Molecules (Basel, Switzerland) · 2025Article
- Multifunctional Tannic Acid and Polyamino Acid Layer-by-Layer Coatings for Tailored Implant Surfaces.ACS biomaterials science & engineering · 2025Article
- pH-Sensitive Cassava Starch/Onion Peel Powder Films as Colorimetric Indicators for Minced Beef Freshness Monitoring.Foods (Basel, Switzerland) · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance is a growing global problem that affects people, animals, the environment, and the economy. Many clinically relevant bacteria have become resistant to antibiotics, and this fact is emerging as one of the major threats to public health. The lack of new antibiotics, which is due to their time-consuming and costly development, exacerbates the problem. Therefore, it is necessary to identify new antimicrobial agents to treat bacterial and fungal infections. Plant extracts, which are valuable sources of bioactive compounds, mainly polyphenols, play an important role as a new strategy to combat pathogenic microorganisms. There is an extensive body of supporting evidence for the potent antibacterial and antifungal activities of polyphenols. Furthermore, some polyphenols show a synergistic effect when combined with antibiotics and antifungals, suggesting a promising alternative for therapeutic strategies against antibiotic resistance. However, only a few articles are found when searching the antibacterial or antifungal activities of polyphenols employing clinical isolates. Hence, this review focuses on the antimicrobial activity of polyphenols and extracts rich in polyphenols on clinical isolates, organized according to the World Health Organization priority pathogens classification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.