ReviewBiomedicines2022
Anorectal and Genital Mucosal Melanoma: Diagnostic Challenges, Current Knowledge and Therapeutic Opportunities of Rare Melanomas.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Comparison of survival outcomes between local excision and radical resection in patients with rectal mucosal melanoma.World journal of surgical oncology · 2026Article
- Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Rectal melanoma: managing a rare cause of rectal bleeding: case report and review of the literature.World journal of surgical oncology · 2026Review
- Not all penile tumours are alike: A rare case of penile melanoma.Urology case reports · 2026Article
- Consider the unexpected! An overlooked, elusive, rare but dramatic diagnosis: anorectal melanoma.Updates in surgery · 2025Article
- Review
- Combination Immunotherapy for Mucosal Melanoma: Molecular Mechanism, Research Status, and Future Directions.Current treatment options in oncology · 2025Review
- Successful multimodality treatment of anorectal melanoma after wide local excision: a case report.Frontiers in oncology · 2025Article
- Case Report: Surgery combined with targeted therapy for metastatic anorectal malignant mucosal melanoma.Frontiers in oncology · 2025Article
- Diagnosis and treatment of 33 patients with primary melanoma of the female reproductive system.Frontiers in oncology · 2025Article
- Primary vulval melanoma and genital lichen sclerosus.Skin health and disease · 2024Article
- Surgical approach of anorectal mucosal melanoma with locoregional disease - a case report.Journal of surgical case reports · 2024Article
- Mucosal Melanoma Clinical Management and Prognostic Implications: A Retrospective Cohort Study.Cancers · 2024Article
- Beyond the Scalpel: Advancing Strategic Approaches and Targeted Therapies in Nonexcisable Melanomas.Journal of skin cancer · 2024Review
- Anorectal Melanoma: A Case Report.Cureus · 2023Article
- The Role of Hedgehog Signaling in the Melanoma Tumor Bone Microenvironment.International journal of molecular sciences · 2023Article
- Genital lichen sclerosus and melanoma; a systematic review.Skin health and disease · 2023Review
- Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways.PloS one · 2023Article
- Management of primary anorectal mucosal melanoma during the COVID-19 pandemic.Ecancermedicalscience · 2023Article
- Progressing Vulvar Melanoma Caused by Instability in cKIT Juxtamembrane Domain: A Case Report and Review of Literature.Current oncology (Toronto, Ont.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucosal melanomas (MM) are rare tumors, being less than 2% of all diagnosed melanomas, comprising a variegated group of malignancies arising from melanocytes in virtually all mucosal epithelia, even if more frequently found in oral and sino-nasal cavities, ano-rectum and female genitalia (vulva and vagina). To date, there is no consensus about the optimal management strategy of MM. Furthermore, the clinical rationale of molecular tumor characterization regarding BRAF, KIT or NRAS, as well as the therapeutic value of immunotherapy, chemotherapy and targeted therapy, has not yet been deeply explored and clearly established in MM. In this overview, focused on anorectal and genital MM as models of rare melanomas deserving of a multidisciplinary approach, we highlight the need of referring these patients to centers with experts in melanoma, anorectal and uro-genital cancers treatments. Taking into account the rarity, the poor outcomes and the lack of effective treatment options for MM, tailored research needs to be promptly promoted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.