Evidence map›Paper›PMID 35052808›Full record

ArticleBiomedicines2022

GABA Administration Ameliorates Sjogren's Syndrome in Two Different Mouse Models.

Min Song, Jide Tian, Blake Middleton, Cuong Q Nguyen, Daniel L Kaufman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Ion channels in dry eye disease.Indian journal of ophthalmology · 2023
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Min SongDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Jide TianDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Blake MiddletonDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Cuong Q NguyenDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-5633-4075
Daniel L KaufmanDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUniversity of Florida · US

Funding

Mapping the T cell receptor/antigen complex and identifying the genetic-based treatment in Sjogren’s syndromeR01DE028544 · NIDCR · UNIVERSITY OF FLORIDA · PI NGUYEN, CUONG Q · 2019 to 2023
$2.6M
Oral GABA treatment as a novel and safe therapy to ameliorate Sjögren’s syndromeR21DE029020 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAUFMAN, DANIEL · 2019 to 2020
$429k
NIDCR NIH HHS R01 DE028544NIDCR NIH HHS R21 DE029020
6 · The paper itself

Abstract

Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltrates in the salivary and lachrymal glands resulting in oral and ocular dryness. There are no clinically approved therapies to slow the progression of SS. Immune cells possess receptors for the neurotransmitter GABA (GABA-Rs) and their activation has immunoregulatory actions. We tested whether GABA administration has potential for amelioration of SS in NOD.B10-H2

Indexed as

autoimmune diseasedry eye diseaseGABAGABA-receptorimmunotherapylacrimal glandsalivary glandSjögren’s syndrome

Identifiers

PMID35052808
PMCPMC8773584
OpenAlexW4206337537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.