Evidence map›Paper›PMID 35052798›Full record

ReviewBiomedicines2022

The Use of

Travis James Philyaw, Adrian Rothenfluh, Iris Titos

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. The use ofFrontiers in cell and developmental biology · 2026
    Review
  2. Science signaling · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. The Stage-Based Model of Addiction-UsingInternational journal of molecular sciences · 2023
    Review
  7. Article
  8. Syntaxin 1 SerScience advances · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Travis James PhilyawMolecular Biology Graduate Program, University of Utah, Salt Lake City, UT 84112, USA.
Adrian RothenfluhDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT 84108, USA.ORCID 0000-0002-3813-5723
Iris TitosMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.
University of Utah · US

Funding

Control of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4M
Mechanisms of alcohol-induced plasticitey mediated by Arf6R01AA026818 · NIAAA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2018 to 2022
$1.7M
ATAC-ing dopaminergic cell identity with single-cell resolutionR21DA049635 · NIDA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2019 to 2020
$419k
Engineering Drosophila that self-administer cocaineR21DA040439 · NIDA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2016 to 2017
$405k
NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R01AA019526, R01AA026818NIAAA NIH HHS R01 AA026818NIDA NIH HHS R21 DA040439NIDA NIH HHS R21 DA049635NIDA NIH HHS R21DA049635
6 · The paper itself

Abstract

The addictive properties of psychostimulants such as cocaine, amphetamine, methamphetamine, and methylphenidate are based on their ability to increase dopaminergic neurotransmission in the reward system. While cocaine and methamphetamine are predominately used recreationally, amphetamine and methylphenidate also work as effective therapeutics to treat symptoms of disorders including attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Although both the addictive properties of psychostimulant drugs and their therapeutic efficacy are influenced by genetic variation, very few genes that regulate these processes in humans have been identified. This is largely due to population heterogeneity which entails a requirement for large samples.

Indexed as

addictionADHDASDcocaineDrosophilagene discoverygeneticsmethamphetaminepsychostimulant responseSUD

Identifiers

PMID35052798
PMCPMC8773124
OpenAlexW4206406156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.