ReviewBiomedicines2022
Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review).
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Combination keratinocytes and fibroblasts cell-based therapy in wound healing: a literature review.Molecular biology reports · 2026Review
- Cutaneous Wound Healing Facilitated by Postbiotic Extract Through Antimicrobial Action and Extracellular Matrix Regulation.International journal of molecular sciences · 2025Article
- Water-Driven Oxygen and Nitric Oxide Release from Porphyrin- and Mn-Based Metal-Organic Framework Enables Accelerated Acute Wound Healing.ACS applied bio materials · 2025Article
- Towards Intelligent Wound Care: Hydrogel-Based Wearable Monitoring and Therapeutic Platforms.Polymers · 2025Review
- Regenerative potential of graphene oxide-chitosan nanocomposite combined with fetal bovine serum on healing of full-thickness skin wound in rats.BMC veterinary research · 2025Article
- Update on the Study of Angiogenesis in Surgical Wounds in Patients with Childhood Obesity.Biomedicines · 2025Review
- Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes.Angiogenesis · 2024Review
- Bioengineering Skin Substitutes for Wound Management-Perspectives and Challenges.International journal of molecular sciences · 2024Review
- Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats.Current gene therapy · 2024Article
- 3D-printed placental-derived bioinks for skin tissue regeneration with improved angiogenesis and wound healing properties.Materials today. Bio · 2023Article
- The Use of Hydrogel-Based Materials for Radioprotection.Gels (Basel, Switzerland) · 2023Review
- Non-Healing Perianal Fistulas: A Clinical Model of Tissue Senescence Impairing Both Tissue Fibrosis and Regenerative Potential.Biomedicines · 2023Review
- Deciphering the focuses and trends in skin regeneration research through bibliometric analyses.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. This review presents an overview of current wound care techniques including skin tissue engineering and biomaterials as a novel and promising approach. We highlight the plasticity and different roles of immune cells, in particular macrophages during various stages of skin wound healing. These aspects are pivotal to promote the regeneration of nonhealing wounds such as ulcers in diabetic patients. We believe that a better understanding of the intrinsic immunomodulatory features of stem cells in implantable skin substitutes will lead to new translational opportunities. This, in turn, will improve skin tissue engineering and regenerative medicine applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.