ArticleBiomedicines2021
Neutrophil to Lymphocyte Ratio (NLR)-A Useful Tool for the Prognosis of Sepsis in the ICU.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.
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Who cites it
74 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- AI-Based Sepsis Prediction in Hospitalized Adults: Systematic Review, Subgroup Meta-Analysis, and Contextual Analysis of Clinical Burden.Journal of medical Internet research · 2026Pooled it
- Neutrophil to lymphocyte ratio in urolithiasis: a systematic review.BMC urology · 2025Pooled it
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis.BMC emergency medicine · 2024Pooled it
- The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial.BMJ (Clinical research ed.) · 2025Trial
- Admission APRI and Early Mortality in ICU Patients with Sepsis: A Retrospective Cohort Study.Microorganisms · 2026Article
- Comparison of nutritional inflammatory indicators for predicting outcomes in patients with sepsis: a retrospective study based on clinical and MIMIC data.BMC infectious diseases · 2026Article
- The A-VIVO score: a novel prognostic tool for predicting mortality in patients with sepsis.Irish journal of medical science · 2026Article
- Validation of SOFA-2 score in sepsis and exploration of its extension with additional immune markers.Journal of intensive medicine · 2026Article
- Monocyte Distribution Width and Composite Biomarker Assessment for Prognostic Stratification of Sepsis in the Intensive Care Unit.Biomedicines · 2026Article
- Combined prognostic value of the neutrophil-to-lymphocyte ratio and serum lactate for 28-day mortality in patients with sepsis-induced pulmonary dysfunction.American journal of translational research · 2026Article
- Severity and 28-day in-hospital mortality of interleukin-6, neutrophil to lymphocyte ratio, and APACHE II score in patients with sepsis.Frontiers in cellular and infection microbiology · 2026Article
- Predictive Value of the Neutrophil‒Lymphocyte Ratio in the Risk Stratification and Prognosis for Patients with Acute Cholangitis: A Single-Center Retrospective Study.Journal of inflammation research · 2026Article
- Sepsis-induced coagulopathy: recent insights on the role and clinical application of neutrophil extracellular trap formation.Scientific reports · 2025Article
- Article
- Staged identification of CAP in fever patients across epidemic environments: modeling & validation.Scientific reports · 2025Article
- Neutrophil-to-lymphocyte ratio predicts mortality for sepsis-induced coagulopathy: a retrospective study.European journal of medical research · 2025Article
- Article
- Early Diagnostic Markers and Risk Stratification in Sepsis: Prognostic Value of Neutrophil-to-Lymphocyte Ratio, Platelets, and the Carmeli Score.Biomedicines · 2025Article
- Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999-2018 cohort.Scientific reports · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a life-threatening medical emergency induced by the body's extreme response to an infection. Despite well-defined and constantly updated criteria for diagnosing sepsis, it is still underdiagnosed worldwide. Among various markers studied over time, the neutrophil to lymphocyte ratio (NLR) recently emerged as a good marker to predict sepsis severity. Our study was a single-center prospective observational study performed in our ICU and included 114 patients admitted for sepsis or septic shock. Neutrophil to lymphocyte ratio (NLR) is easy to perform, CBC being one of the standard blood tests routinely performed upon admission for all ICU patients. We found that NLR was increased in all patients with sepsis and significantly raised in those with septic shock. NLR correlates significantly with sepsis severity evaluated by the SOFA score (R = 0.65) and also with extensively studied sepsis prognosis marker presepsin (R = 0.56). Additionally, NLR showed good sensitivity (47%) and specificity (78%) with AUC = 0.631 (
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