Evidence map›Paper›PMID 35052709›Full record

ArticleBiomedicines2021

Platelet Toll-like Receptor 4-Related Innate Immunity Potentially Participates in Transfusion Reactions Independent of ABO Compatibility: An Ex Vivo Study.

Chien-Sung Tsai, Mei-Hua Hu, Yung-Chi Hsu, Go-Shine Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Chien-Sung TsaiDepartment of Surgery, Division of Cardiovascular Surgery, Tri-Service General Hospital, Taipei 114, Taiwan.
Mei-Hua HuDepartment of Pediatrics, Division of Pediatric General Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Yung-Chi HsuNational Defense Medical Center, Department of Anesthesiology, Tri-Service General Hospital, Taipei 114, Taiwan.ORCID 0000-0002-5613-5620
Go-Shine HuangNational Defense Medical Center, Department of Anesthesiology, Tri-Service General Hospital, Taipei 114, Taiwan.
Tri-Service General Hospital · TWChang Gung University · TW

Funding

Ministry of Science and Technology MOST 107-2314- B-016-016Tri-Service General Hospital TSGH-C104-105Tri-Service General Hospital TSGH-C105-101Tri-Service General Hospital TSGH-C106-085
6 · The paper itself

Abstract

The role of platelet TLR4 in transfusion reactions remains unclear. This study analyzed platelet TLR4 and certain damage-associated molecular patterns (DAMPs) and evaluated how ABO compatibility affected TLR4 expression after a simulated ex vivo transfusion. A blood bank was the source of donor red blood cells. Blood from patients undergoing cardiac surgery was processed to generate a washed platelet suspension to which the donor blood was added in concentrations 1, 5, and 10% (

Indexed as

blood mixinginnate immunityplatelettoll-like receptor 4transfusion reaction

Identifiers

PMID35052709
PMCPMC8772939
OpenAlexW4225588601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.