Evidence map›Paper›PMID 35052695›Full record

ArticleBiomedicines2021

Combination Biomarker of Immune Checkpoints Predict Prognosis of Urothelial Carcinoma.

Chung-Ying Tsai, Hsiang-Cheng Chi, Ren-Chin Wu, Cheng-Hao Weng, Tzong-Shyuan Tai, Chan-Yu Lin, Tai-Di Chen, Ya-Hui Wang, Li-Fang Chou, Shen-Hsing Hsu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Chung-Ying TsaiKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Hsiang-Cheng ChiGraduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.
Ren-Chin WuDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.ORCID 0000-0003-1439-0874
Cheng-Hao WengKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Tzong-Shyuan TaiAdvanced Immunology Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.ORCID 0000-0003-0575-914X
Chan-Yu LinKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Tai-Di ChenDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Ya-Hui WangInstitute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan.
Li-Fang ChouKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-0189-1699
Shen-Hsing HsuKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0003-3527-4151
Po-Hung LinGraduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0001-8245-4302
See-Tong PangGraduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Hung-Yu YangKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0001-6826-9717
Chang Gung University · TWChang Gung Memorial Hospital · TWJohns Hopkins University · USChina Medical University · TW

Funding

Linkou Chang Gung Memorial Hospital CMRPG3H1701-3 and CMRPG3L0721
6 · The paper itself

Abstract

In contrast to Western counties, the incidence of urothelial carcinoma (UC) remains mar-edly elevated in Taiwan. Regulatory T cells (Tregs) play a crucial role in limiting immune responses within the tumor microenvironment. To elucidate the relationship between immune checkpoints in the tumor immune microenvironment and UC progression, we utilize the Gene Expression Omnibus (GEO) to analyze a microarray obtained from 308 patients with UC. We observed that the expression level of

Indexed as

CD276immune checkpointsregulatory T cellsTIM-3urothelial carcinoma

Identifiers

PMID35052695
PMCPMC8772792
OpenAlexW4200019143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.