Evidence map›Paper›PMID 35052691›Full record

ArticleBiomedicines2021

Sensitive Electrochemical Detection of Phosphorylated-Tau Threonine 231 in Human Serum Using Interdigitated Wave-Shaped Electrode.

Hien T Ngoc Le, Sungbo Cho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hien T Ngoc LeDepartment of Electronic Engineering, Gachon University, Seongnam-si 13120, Korea.ORCID 0000-0001-9266-2447
Sungbo ChoDepartment of Electronic Engineering, Gachon University, Seongnam-si 13120, Korea.ORCID 0000-0003-3839-6410
Gachon University · KR

Funding

Korea Environmental Industry and Technology Institute "Technology Development Project for Biological Hazards Management in Indoor Air" Project, funded by Korea Ministry of Environment (MOE)(G232021010381)National Research Foundation of Korea 2018M3A9F1023691National Research Foundation of Korea 2019R1G1A1100610the GRRC program of Gyeonggi province GRRC-Gachon2020(B01), AI-based Medical Image Analysis
6 · The paper itself

Abstract

The development of an electrochemical biosensor for the detection of phosphorylated-tau threonine 231 (p-tau231), a biomarker of Alzheimer's disease (AD), has yet to be achieved. Therefore, in this study, we developed a simple, small size, cheap, and sensitive electrochemical biosensor based on an interdigitated wave-shaped electrode via an activated self-assembled monolayer to preserve a specific anti-p-tau231 antibody (IWE/SAM/EDC-NHS/anti-p-tau231). Detection of p-tau231 in human serum (HS) using the biosensor was undertaken using electrochemical impedance spectroscopy (EIS). The change in charge-transfer resistance (R

Indexed as

Alzheimer’s diseasebinding affinityelectrochemical biosensorelectrochemical impedance spectroscopymicro-interdigitated electrodephosphorylated-tau threonine 231

Identifiers

PMID35052691
PMCPMC8773253
OpenAlexW4200621836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.