ReviewAntioxidants (Basel, Switzerland)2022
Antioxidant Paradox in Male Infertility: 'A Blind Eye' on Inflammation.
Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Male testosterone synthesis disorders: oxidative stress pathways, regulatory mechanisms, potential of antioxidant therapy, and botanical medicine prospects.Asian journal of andrology · 2026Review
- Influence of Very Short-Term Sexual Abstinence on Basic Semen Parameters and Sperm Chromatin Status: A Preliminary Study.International journal of molecular sciences · 2026Article
- Redox-Genomic Crosstalk: Linking Oxidative Stress, Sperm DNA Fragmentation, and Epigenetics in Personalized Management of Male Infertility.Journal of personalized medicine · 2026Review
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Mito-TEMPO improves preservation of cooled canine semen over a 72-hour period of storage.Iranian journal of veterinary research · 2026Article
- Idiopathic male infertility revisited: can redox endophenotypes reframe the 'idiopathic' label?Frontiers in endocrinology · 2026Review
- Reductive stress and the role of antioxidants in male infertility: a narrative review.Archives of gynecology and obstetrics · 2025Review
- Pyrroloquinoline Quinone Mitigates Testicular Injury and Reduces Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Rats with Testicular Ischemia-Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2025Article
- Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management-A Narrative Review.Metabolites · 2025Review
- Lycopene in male infertility.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Influence of Body Mass Index (BMI) and Waist-Hip Ratio (WHR) on Selected Semen Parameters.International journal of molecular sciences · 2025Article
- Seminal FBiology · 2025Article
- From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health.Metabolites · 2025Review
- Impact of Reductive Stress on Human Infertility: Underlying Mechanisms and Perspectives.International journal of molecular sciences · 2024Review
- Nutritional Benefits of Lycopene and Beta-Carotene: A Comprehensive Overview.Food science & nutrition · 2024Review
- The Role of Cells and Cytokines in Male Infertility Induced by Orchitis.The world journal of men's health · 2024Review
- Reliable Detection of Excessive Sperm Ros Production in Subfertile Patients: How Many Men with Oxidative Stress?Antioxidants (Basel, Switzerland) · 2024Article
- Supplementation of sperm cryopreservation media with HScientific reports · 2024Article
- The impact of Apis dorsata forest honey administration on follicle-stimulating hormone and luteinizing hormone levels in rats (Open veterinary journal · 2024Article
- Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects.Frontiers in endocrinology · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of male infertility involves various interlinked endogenous pathways. About 50% of the cases of infertility in men are idiopathic, and oxidative stress (OS) reportedly serves as a central mechanism in impairing male fertility parameters. The endogenous antioxidant system operates to conserve the seminal redox homeostasis required for normal male reproduction. OS strikes when a generation of seminal reactive oxygen species (ROS) overwhelms endogenous antioxidant capacity. Thus, antioxidant treatment finds remarkable relevance in the case of idiopathic male infertility or subfertility. However, due to lack of proper detection of OS in male infertility, use of antioxidant(s) in some cases may be arbitrary or lead to overuse and induction of 'reductive stress'. Moreover, inflammation is closely linked to OS and may establish a vicious loop that is capable of disruption to male reproductive tissues. The result is exaggeration of cellular damage and disruption of male reproductive tissues. Therefore, limitations of antioxidant therapy in treating male infertility are the failure in the selection of specific treatments targeting inflammation and OS simultaneously, two of the core mechanisms of male infertility. The present review aims to elucidate the antioxidant paradox in male infertility treatment, from the viewpoints of both induction of reductive stress as well as overlooking the inflammatory consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.