Evidence map›Paper›PMID 35052616›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157-Lipoic Acid Hybrids for the Treatment of Alzheimer's Disease.

Ángel Cores, Patrycja Michalska, José Miguel Pérez, Enrique Crisman, Clara Gómez, Mercedes Villacampa, José Carlos Menéndez, Rafael León

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. VANL-100 Attenuates Beta-Amyloid-Induced Toxicity in SH-SY5Y Cells.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ángel CoresUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Patrycja MichalskaDepartment of Chemistry, Imperial College London, London SW7 2BX, UK.
José Miguel PérezUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Enrique CrismanInstituto de Investigación Sanitaria, Hospital Universitario de la Princesa, 28006 Madrid, Spain.
Clara GómezInstituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), 28006 Madrid, Spain.
Mercedes VillacampaUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
José Carlos MenéndezUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.ORCID 0000-0002-0560-8416
Rafael LeónInstituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0003-4017-5756

Funding

Comunidad de Madrid B2017/BMD-3813Comunidad de Madrid B2017/BMD-3827Instituto de Salud Carlos III PI17/01700Instituto de Salud Carlos III PI20/00433Ministry of Science, Technology and Productive Innovation RTI2018-097662-B-I00
6 · The paper itself

Abstract

Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na

Indexed as

CGP37157lipoic acidneuroprotectionNRF2 induction

Identifiers

PMID35052616
PMCPMC8772772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.