Evidence map›Paper›PMID 35052607›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium.

Xue Yang, Usha Rai, Jin-Yong Chung, Noriko Esumi

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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  17. The many faces of SIRT6 in the retina and retinal pigment epithelium.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xue YangWilmer Eye Institute, Johns Hopkins University School of Medicine, Smith Building Room 3041, 400 North Broadway, Baltimore, MD 21231, USA.ORCID 0000-0002-1288-5569
Usha RaiWilmer Eye Institute, Johns Hopkins University School of Medicine, Smith Building Room 3041, 400 North Broadway, Baltimore, MD 21231, USA.
Jin-Yong ChungWilmer Eye Institute, Johns Hopkins University School of Medicine, Smith Building Room 3041, 400 North Broadway, Baltimore, MD 21231, USA.
Noriko EsumiWilmer Eye Institute, Johns Hopkins University School of Medicine, Smith Building Room 3041, 400 North Broadway, Baltimore, MD 21231, USA.ORCID 0000-0001-7995-4023
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
Bayer AG grant to Johns Hopkins University/Wilmer Eye Institute WILM003BrightFocus Foundation M2015220NEI NIH HHS P30EY001765RESEARCH TO PREVENT BLINDNESS unrestricted funds to Wilmer Eye InstituteWilmer Pooled Professor Research Fund PPF 2016
6 · The paper itself

Abstract

Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO

Indexed as

anti-oxidantcatalaseIKKbetaNF-kappaBoxidative stressretinal pigment epitheliumsex differencessodium iodate

Identifiers

PMID35052607
PMCPMC8773095
OpenAlexW4205737377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.