Evidence map›Paper›PMID 35052490›Full record

ArticleGenes2022

A Simulated Shift Work Schedule Does Not Increase DNA Double-Strand Break Repair by NHEJ in the

Lydia Bergerson, Caleb Fitzmaurice, Tyler Knudtson, Halle McCormick, Alder M Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Circadian clock and cancer.Military Medical Research · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lydia BergersonDepartment of Biology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
Caleb FitzmauriceDepartment of Biology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
Tyler KnudtsonDepartment of Biology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
Halle McCormickDepartment of Biology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
Alder M YuDepartment of Biology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.ORCID 0000-0002-7599-7357
University of Wisconsin–La Crosse · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term shift work is widely believed to increase the risk of certain cancers, but conflicting findings between studies render this association unclear. Evidence of interplay between the circadian clock, cell cycle regulation, and DNA damage detection machinery suggests the possibility that circadian rhythm disruption consequent to shift work could alter the DNA double-strand break (DSB) repair pathway usage to favor mutagenic non-homologous end-joining (NHEJ) repair. To test this hypothesis, we compared relative usage of NHEJ and single-strand annealing (SSA) repair of a complementary ended chromosomal double-stranded break using the Repair Reporter 3 (Rr3) system in

Indexed as

Chromosome BreakageDNA Breaks, Double-StrandedDNA End-Joining RepairAnimalsAnimals, NewbornDrosophila melanogasterDrosophila ProteinsFemaleMaleShift Work ScheduleDrosophila Proteinscircadian rhythmDNA repairDrosophilamutationNHEJ

Identifiers

PMID35052490
PMCPMC8774994
OpenAlexW4206482756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.