Evidence map›Paper›PMID 35052454›Full record

ArticleGenes2022

Morning Cortisol and Circulating Inflammatory Cytokine Levels: A Mendelian Randomisation Study.

Skanda Rajasundaram, Rezbieara P Rahman, Benjamin Woolf, Sizheng Steven Zhao, Dipender Gill

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Observational
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Skanda RajasundaramKellogg College, University of Oxford, Oxford OX2 6PN, UK.
Rezbieara P RahmanClinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George's, University of London, London SW7 0RE, UK.ORCID 0000-0002-4146-1300
Benjamin WoolfMedical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol BS8 1TU, UK.ORCID 0000-0002-1505-2570
Sizheng Steven ZhaoCentre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Science, School of Biological Sciences, Faculty of Biological Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PG, UK.ORCID 0000-0002-3558-7353
Dipender GillClinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George's, University of London, London SW7 0RE, UK.ORCID 0000-0001-7312-7078
St George's, University of London · GBManchester Academic Health Science Centre · GBUniversity of Bristol · GBUniversity of Oxford · GB

Funding

British Heart Foundation RE/18/4/34215Department of Health CL-2020-16-001Department of Health ES/P000630/1
6 · The paper itself

Abstract

Cortisol exerts a broad anti-inflammatory effect on the immune system. Inflammatory cytokines contribute to the molecular signalling pathways implicated in various autoimmune and inflammatory conditions. However, the mechanisms by which cortisol modulates such signalling pathways remain uncertain. Leveraging summary-level data from the CORtisol NETwork (CORNET,

Indexed as

Mendelian Randomization AnalysisPolymorphism, Single NucleotideCytokinesGenome-Wide Association StudyHumansHydrocortisoneInflammationRisk FactorsCytokinesHydrocortisonecytokinesinflammationMendelian randomisationmorning cortisolsteroid

Identifiers

PMID35052454
PMCPMC8774857
OpenAlexW4205651294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.