Evidence map›Paper›PMID 35052452›Full record

ArticleGenes2022

Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.

Andreas Kühnapfel, Katrin Horn, Ulrike Klotz, Michael Kiehntopf, Maciej Rosolowski, Markus Loeffler, Peter Ahnert, Norbert Suttorp, Martin Witzenrath, Markus Scholz

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Andreas KühnapfelInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0003-3668-0784
Katrin HornInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Ulrike KlotzInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Michael KiehntopfInstitute for Clinical Chemistry and Laboratory Diagnostics, Jena University Hospital, 07740 Jena, Germany.
Maciej RosolowskiInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Peter AhnertInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-1771-0856
Norbert SuttorpDivision of Infectiology and Pneumonology, Medical Department, Charité-Berlin University Medicine, 13353 Berlin, Germany.
Martin WitzenrathDivision of Infectiology and Pneumonology, Medical Department, Charité-Berlin University Medicine, 13353 Berlin, Germany.ORCID 0000-0002-9787-5633
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-4059-1779
Leipzig University · DECharité - Universitätsmedizin Berlin · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommunity-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity.

methodsFor up to

results102 SNPs from 14 loci showed genome-wide significant associations with five of the cytokines. The most interesting associations were found at 6p21.1 for VEGF (

conclusionThis is the first context-specific genetic association study of blood cytokine concentrations in CAP patients revealing numerous biologically plausible candidate genes. Two of the loci were also associated with atherosclerosis with probable common or consecutive pathomechanisms.

Indexed as

Gene Expression RegulationAdolescentAdultAgedAged, 80 and overBiomarkersCase-Control StudiesCommunity-Acquired InfectionsCytokinesFemaleFollow-Up StudiesGenome-Wide Association StudyHumansLongitudinal StudiesMaleMiddle AgedBiomarkersCytokinescolocalisation analysisconditional and joint analysiscytokinegenome-wide association studyMetaXcan analysis

Identifiers

PMID35052452
PMCPMC8774373
OpenAlexW3205662344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.