ArticleGenes2021
Single-Cell Analysis of Aneurysmal Aortic Tissue in Patients with Marfan Syndrome Reveals Dysfunctional TGF-β Signaling.
Open access · goldAbstract read
In one paragraph
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 38 citations in OpenAlex.
- The aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction.Cardiovascular research · 2026Review
- Exercise-Induced Regulation of LncRNAs: Mechanistic Insights and Clinical Translation in Cardiovascular Health.Journal of cardiovascular translational research · 2026Review
- Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).Molecular medicine reports · 2026Review
- Mechanotransduction in Marfan Syndrome and Related Aortic Disorders: Insights from Transcriptomic Analyses.Genes · 2026Review
- The Efficacy of Antihypertensive Drugs and miR-632 Inhibition on Parietal Remodeling in a Model of Marfan Thoracic Aortic Aneurysm.Biomolecules · 2026Article
- Structural and Signaling Mechanisms of Aortic Wall Failure in Heritable Thoracic Aortic Disease.Cells · 2026Review
- Focal adhesion proteins confer smooth muscle anoikis resistance and protection against aortic aneurysm and dissection.JCI insight · 2026Article
- Integrative Proteogenomic Analysis Identifies Genetically Supported Plasma Proteins, Metabolites, and Pathways in Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Loeys-Dietz syndrome subtypes exhibit distinct clinical behavior and aortic cellular transcriptomic profiles.JTCVS open · 2025Article
- Induced Pluripotent (iPSC) and Mesenchymal (MSC) Stem Cells for In Vitro Disease Modeling and Regenerative Medicine.International journal of molecular sciences · 2025Review
- Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF-β Pathway Inhibition.Journal of the American Heart Association · 2025Article
- TGFBR3 dependent mechanism of TGFB2 in smooth muscle cell differentiation and implications for TGFB2-related aortic aneurysm.Stem cells translational medicine · 2025Article
- Exploring Disparities in Atherosclerosis Comorbidity with Aortic Aneurysm.Biomedicines · 2025Review
- Heterogeneous Cardiac-Derived and Neural Crest-Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Olfactory Receptors and Aortic Aneurysm: Review of Disease Pathways.Journal of clinical medicine · 2024Review
- CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID.Nature cardiovascular research · 2024Article
- miRNA-Driven Regulation of Endothelial-to-Mesenchymal Transition Differs among Thoracic Aortic Aneurysms.Cells · 2024Article
- Coding and Non-Coding Transcriptomic Landscape of Aortic Complications in Marfan Syndrome.International journal of molecular sciences · 2024Review
- Characterization and expression analysis of GLABRA3 (GL3) genes in cotton: insights into trichome development and hormonal regulation.Molecular biology reports · 2024Article
- Regnase-1 overexpression as a therapeutic approach of Marfan syndrome.Molecular therapy. Methods & clinical development · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 1 country.
Ashley DawsonDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Yanming LiDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Yang LiDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Pingping RenDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Hernan G VasquezDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Chen ZhangDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Kimberly R RebelloDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Waleed AgeediDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Alon R AzaresDepartment of Cardiovascular Surgery, Texas Heart Institute, Houston, TX 77030, USA.
Aladdein Burchett MattarDivision of Cardiothoracic Transplantation and Circulatory Support, Baylor College of Medicine, Houston, TX 77030, USA.
Mary Burchett SheppardSaha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-0026-8640
Hong S LuSaha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-0577-2558
Joseph S CoselliDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Lisa A CassisDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
Alan DaughertySaha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-2093-3775
Ying H ShenDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4119-115X
Scott A LeMaireDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8736-4266
Baylor College of Medicine · USUniversity of Kentucky · US
Funding
Research Training Program in Cardiovascular SurgeryT32HL139430 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Todd K Rosengart · 2018 to 2026
$2.9MPro-inflammatory Pyroptotic Cell Death in Aortic DegenerationR01HL158157 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2021 to 2024
$2.4MTargeting ER Stress To Treat Aortic Aneurysms and DissectionsR01HL131980 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2016 to 2019
$1.7MMitochondrial Damage-Induced Necroptotic Cell Death in SporadicAscending Thoracic Aortic Aneurysms and DissectionsR01HL143359 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2018 to 2021
$1.6MPharmacological Mechanistic Insights into Thoracic Aortic AneurysmK01HL149984 · NHLBI · UNIVERSITY OF KENTUCKY · PI SHEPPARD, MARY BURCHETT · 2021 to 2025
$886kNHLBI NIH HHS K01 HL149984NHLBI NIH HHS R01 HL131980NHLBI NIH HHS R01 HL143359NHLBI NIH HHS R01 HL158157NHLBI NIH HHS T32 HL139430
Abstract
The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (
Indexed as
AdultAortic Aneurysm, ThoracicCase-Control StudiesCell DifferentiationFemaleGene Expression RegulationHumansMaleMarfan SyndromeReceptors, Transforming Growth Factor betaSignal TransductionSingle-Cell AnalysisTransforming Growth Factor betaYoung AdultReceptors, Transforming Growth Factor betaTransforming Growth Factor betaaneurysmMarfan syndromemolecular biologysmooth muscle cell differentiation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.