Evidence map›Paper›PMID 35052431›Full record

ArticleGenes2021

Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity.

Anna Lessmark, Gad Hatem, Györgyi Kovacs, Marta Vitai, Emma Ahlqvist, Tiinamaija Tuomi, Laszlo Koranyi, Leif Groop, Rashmi B Prasad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Anna LessmarkLund University Diabetes Centre, Lund University, CRC, Skåne University Hospital Malmö, 214 28 Malmö, Sweden.
Gad HatemGenomics, Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, CRC, 214 28 Malmö, Sweden.
Györgyi KovacsHeart Center Foundation, DRC, 8230 Balatonfured, Hungary.
Marta VitaiHeart Center Foundation, DRC, 8230 Balatonfured, Hungary.
Emma AhlqvistGenomics, Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, CRC, 214 28 Malmö, Sweden.
Tiinamaija TuomiAbdominal Center, Endocrinology, Helsinki University Central Hospital, Research Program for Clinical and Molecular Metabolism, University of Helsinki, 00260 Helsinki, Finland.
Laszlo KoranyiHeart Center Foundation, DRC, 8230 Balatonfured, Hungary.
Leif GroopGenomics, Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, CRC, 214 28 Malmö, Sweden.
Rashmi B PrasadGenomics, Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, CRC, 214 28 Malmö, Sweden.ORCID 0000-0002-4400-6741
Lund University · SEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the

Indexed as

Polymorphism, Single NucleotideAngiopoietin-Like Protein 3Cohort StudiesDiabetes Mellitus, Type 2DyslipidemiasFemaleGenomic ImprintingGenotypeHumansLipidsLipoprotein LipaseMaleObesityParentsPhenotypeQuantitative Trait LociAngiopoietin-Like Protein 3ANGPTL3 protein, humanLipidsLipoprotein LipaseLPL protein, humanANGPTL3dyslipidemiahuman geneticsLPLobesityparent-of-origin

Identifiers

PMID35052431
PMCPMC8774740
OpenAlexW4200367459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.