Evidence map›Paper›PMID 35052430›Full record

ArticleGenes2021

Capturing SNP Association across the NK Receptor and HLA Gene Regions in Multiple Sclerosis by Targeted Penalised Regression Models.

Sean M Burnard, Rodney A Lea, Miles Benton, David Eccles, Daniel W Kennedy, Jeannette Lechner-Scott, Rodney J Scott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Sean M BurnardSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.ORCID 0000-0003-2149-3556
Rodney A LeaSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.
Miles BentonHuman Genomics, Kenepuru Science Centre, Institute of Environmental Science and Research, Wellington 5240, New Zealand.
David EcclesMalaghan Institute of Medical Research, Wellington 6242, New Zealand.ORCID 0000-0003-4634-4995
Daniel W KennedyAustralian Centre of Excellence for Mathematical and Statistical frontiers, Queensland University of technology, Brisbane, QLD 4000, Australia.
Jeannette Lechner-ScottCentre for Brain and Mental Health (CBMHR), Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW 2305, Australia.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.ORCID 0000-0001-7724-3404
John Hunter Hospital · AUARC Centre of Excellence for Mathematical and Statistical Frontiers · AUHunter Medical Research Institute · AUMalaghan Institute of Medical Research · NZNew Zealand Institute for Public Health and Forensic Science · NZQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional genome-wide association studies (GWASs) of complex traits, such as Multiple Sclerosis (MS), are reliant on per-SNP

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociCase-Control StudiesCohort StudiesFemaleGenome-Wide Association StudyHLA AntigensHumansMaleMultiple SclerosisReceptors, Natural Killer CellRegression AnalysisHLA AntigensReceptors, Natural Killer Cellelastic netgene–gene interactiongenetic wide association study (GWAS)human leukocyte antigen (HLA) complexleukocyte receptor complex (LRC)multiple sclerosis (MS)multi-variate regression analysisnatural killer cellsnatural killer gene complex (NKC)single nucleotide polymorphisms (SNPs)

Identifiers

PMID35052430
PMCPMC8774935
OpenAlexW4200388878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.