ReviewGenes2021
Ischemic Stroke Genetics: What Is New and How to Apply It in Clinical Practice?
Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- Association of MTHFR and platelet-related blood cell ratio parameters with ischemic stroke in Gansu population.BMC cardiovascular disorders · 2026Article
- Article
- Functional connectivity and graph theory of impaired central visual pathways in acute ischemic stroke based on functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Multi-omics integrative analysis reveals novel genetic loci and candidate genes for ischemic stroke.Molecular therapy. Nucleic acids · 2025Article
- Clinical Perspectives on Stroke Prevention in Patients with Non-valvular Atrial Fibrillation in the Philippines.Cureus · 2025Review
- Genetic Architecture of Ischemic Stroke: Insights from Genome-Wide Association Studies and Beyond.Journal of cardiovascular development and disease · 2025Review
- Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach.Scientific reports · 2025Article
- Correlations between ATF3 polymorphisms and ischemic stroke in Dali, Yunnan Province, as determined by a case-control study.BMC neurology · 2025Article
- Women Veterans' Stroke Risk Factors: Identified Prevention Methods and Knowledge Gaps.Military medicine · 2025Article
- Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke.Journal of central nervous system disease · 2025Article
- Inflammation and endothelial gene polymorphism are associated with ischemic stroke.Frontiers in neurology · 2025Article
- The Impact of Plasma Homocysteine Level and Estimated Glomerular Filtration Rate on Neurological Function at Admission in Patients with Acute Ischemic Stroke: A Retrospective Cross-Sectional Study.Neuropsychiatric disease and treatment · 2025Article
- Article
- HIF-1α knockdown attenuates inflammation and oxidative stress in ischemic stroke male rats via CXCR4/NF-κB pathway.Brain and behavior · 2024Article
- Association of Glycoprotein IIIa PlA1/A2 Polymorphism with Risk of Stroke: Updated Meta-Analysis.Current issues in molecular biology · 2024Article
- Therapeutic effect and psychological impact of aspirin plus edaravone on patients with cerebral infarction.World journal of psychiatry · 2024Article
- The Roles of NOTCH3 p.R544C and Thrombophilia Genes in Vietnamese Patients With Ischemic Stroke: Study Involving a Hierarchical Cluster Analysis.JMIR bioinformatics and biotechnology · 2024Article
- Comparison of efficacy and safety between loading-dose atorvastatin and rosuvastatin in cerebral infarction.American journal of translational research · 2024Article
- The NLRP3 inflammasome in ischemic stroke.Frontiers in stroke · 2024Review
- Genetics in Ischemic Stroke: Current Perspectives and Future Directions.Journal of cardiovascular development and disease · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic causes make a significant contribution to ischemic stroke genesis, especially in early-onset stroke. Several stroke classification systems based on genetic information corresponding to various stroke phenotypes were proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke, however, both have their own limitations. Genome-wide association studies and next generation sequencing are more efficient, promising and increasingly used for daily diagnostics. Some monogenic disorders, despite covering only about 7% of stroke etiology, may cause well-known clinical manifestations that include stroke. Polygenic disorders are more frequent, causing about 38% of all ischemic strokes, and their identification is a rapidly developing field of modern stroke genetics. Current advances in human genetics provide opportunity for personalized prevention of stroke and novel treatment possibilities. Genetic risk scores (GRS) and extended polygenic risk scores (PRS) estimate cumulative contribution of known genetic factors to a specific outcome of stroke. Combining those scores with clinical information and risk factor profiles might result in better primary stroke prevention. Some authors encourage the use of stroke gene panels for stroke risk evaluation and further stroke research. Moreover, new biomarkers for stroke genetic causes and novel targets for gene therapy are on the horizon. In this article, we summarize the latest evidence and perspectives of ischemic stroke genetics that could be of interest to the practitioner and useful for day-to-day clinical work.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.