Evidence map›Paper›PMID 35052365›Full record

Observational studyGenes2021

An Emergent Nexus between Striae and Thoracic Aortic Dissection.

Benjamin J Landis, Courtney E Vujakovich, Lindsey R Elmore, Saila T Pillai, Lawrence S Lee, Jeffrey E Everett, Larry W Markham, John W Brown, Phillip J Hess, Joel S Corvera

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Benjamin J LandisRiley Hospital for Children Heart Center, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Courtney E VujakovichRiley Hospital for Children Heart Center, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lindsey R ElmoreRiley Hospital for Children Heart Center, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Saila T PillaiDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lawrence S LeeDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jeffrey E EverettDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Larry W MarkhamRiley Hospital for Children Heart Center, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
John W BrownDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Phillip J HessDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Joel S CorveraDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineRiley Hospital for Children · US

Funding

Indiana Pediatric Scientist Award(IPSA)K12HD068371 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI CLAPP, DAVID W · 2013 to 2017
$1.9M
Investigating the role of mitochondria in thoracic aortic aneurysm pathogenesisK23HL141667 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LANDIS, BENJAMIN JOHN · 2019 to 2023
$810k
NIH HHS K12 HD068371NIH HHS K23 HL141667
6 · The paper itself

Abstract

Current approaches to stratify the risk for disease progression in thoracic aortic aneurysm (TAA) lack precision, which hinders clinical decision making. Connective tissue phenotyping of children with TAA previously identified the association between skin striae and increased rate of aortic dilation. The objective of this study was to analyze associations between connective tissue abnormalities and clinical endpoints in adults with aortopathy. Participants with TAA or aortic dissection (TAD) and trileaflet aortic valve were enrolled from 2016 to 2019 in the setting of cardiothoracic surgical care. Data were ascertained by structured interviews with participants. The mean age among 241 cases was 61 ± 13 years. Eighty (33%) had history of TAD. While most participants lacked a formal syndromic diagnosis clinically, connective tissue abnormalities were identified in 113 (47%). This included 20% with abdominal hernia and 13% with skin striae in atypical location. In multivariate analysis, striae and hypertension were significantly associated with TAD. Striae were associated with younger age of TAD or prophylactic aortic surgery. Striae were more frequent in TAD cases than age- and sex-matched controls. Thus, systemic features of connective tissue dysfunction were prevalent in adults with aortopathy. The emerging nexus between striae and aortopathy severity creates opportunities for clinical stratification and basic research.

Indexed as

AortaAortic Aneurysm, ThoracicAortic DissectionAortic ValveFemaleHumansMaleMiddle Agedconnective tissuesMarfan syndromestriaethoracic aortic aneurysmthoracic aortic dissection

Identifiers

PMID35052365
PMCPMC8774627
OpenAlexW4200464620

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.