ArticleGenes2021
MEK Inhibition in a Newborn with
Open access · goldAbstract readCase Reports
In one paragraph
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Trametinib as a targeted treatment in cardiac and lymphatic presentations of Noonan syndrome.Frontiers in pediatrics · 2025Pooled it
- Rigosertib Reverses Hypertrophic Cardiomyopathy in Noonan Syndrome.Circulation · 2026Article
- Clinical consensus guidelines for the management of Noonan syndrome in Japan.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026Article
- Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report.Clinical case reports · 2026Article
- Trametinib for multiple non-ossifying fibromas due to KRAS mosaic mutations: two case reports.Communications medicine · 2026Article
- The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations.Prenatal diagnosis · 2026Review
- Pulmonary Hypertension in Pediatric Patients with Noonan Syndrome Undergoing Cardiac Catheterization.Pediatric cardiology · 2026Article
- Domain-specific phenotypic profiles in RAF1-related Noonan syndrome.European journal of human genetics : EJHG · 2026Article
- Effects of MEK-inhibitor treatment in infants with lymphatic abnormalities in noonan syndrome.Frontiers in pediatrics · 2026Article
- NF-κB signaling as a critical inflammatory node in pulmonary arterial hypertension: from vascular remodeling to right heart failure.Frontiers in immunology · 2026Review
- Hypertrophic cardiomyopathy: comprehensive insights into pathogenic genes and genotype-phenotype associations.Frontiers in cell and developmental biology · 2026Review
- Phenotypic Analysis of Embryos in a Noonan Syndrome Model Mouse With the Rit1 A57G Mutation.Molecular genetics & genomic medicine · 2025Article
- Trametinib alters contractility of paediatric Noonan syndrome-associated hypertrophic myocardial tissue slices.ESC heart failure · 2025Article
- RVOT Stenting and Trametinib in an Infant With Noonan Syndrome, Pulmonary Stenosis, and Hypertrophic Cardiomyopathy.JACC. Case reports · 2025Article
- Cardiac MRI Characteristics of Noonan Syndrome Associated With Hypertrophic Cardiomyopathy and Congenital Heart Disease.Korean journal of radiology · 2025Article
- Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy.JACC. Basic to translational science · 2025Article
- ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3.BMC medical genomics · 2024Article
- Noonan Syndrome: Relation of Genotype to Cardiovascular Phenotype-A Multi-Center Retrospective Study.Genes · 2024Article
- Refractory Chylothorax and Ventricular Hypertrophy Treated with Trametinib in a Patient with Noonan Syndrome: 18-Month Follow-Up.Children (Basel, Switzerland) · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 2 countries.
Alessandro MussaDepartment of Public Health and Pediatric Sciences, University of Torino, 10126 Torino, Italy.
Diana CarliDepartment of Public Health and Pediatric Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0001-5690-6504
Elisa GiorgioDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
Anna Maria VillarPediatric Cardiology Unit, Regina Margherita Children's Hospital, Città Della Salute e Della Scienza di Torino, 10126 Torino, Italy.
Simona CardaropoliDepartment of Public Health and Pediatric Sciences, University of Torino, 10126 Torino, Italy.
Caterina CarbonaraNeonatal Intensive Care Unit, Sant'Anna Hospital, Città Della Salute e Della Scienza di Torino, 10126 Torino, Italy.
Maria Francesca CampagnoliNeonatal Intensive Care Unit, Sant'Anna Hospital, Città Della Salute e Della Scienza di Torino, 10126 Torino, Italy.
Paolo GallettoNeonatal Intensive Care Unit, Sant'Anna Hospital, Città Della Salute e Della Scienza di Torino, 10126 Torino, Italy.
Martina PalumboLaboratory of Oncogenomics, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.ORCID 0000-0002-1548-0890
Simone OlivieriDepartment of Public Health and Pediatric Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-6879-5909
Claudio IsellaLaboratory of Oncogenomics, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.
Gregor AndelfingerCardiovascular Genetics, Department of Pediatrics, CHU Sainte Justine, Université de Montréal, Montreal, QC H3T 1C5, Canada.
Marco TartagliaGenetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146 Rome, Italy.ORCID 0000-0001-7736-9672
Giovanni BottaDepartment of Pathology, Sant'Anna Hospital, Città Della Salute e Della Scienza di Torino, 10126 Torino, Italy.
Alfredo BruscoDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-8318-7231
Enzo MedicoLaboratory of Oncogenomics, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.
Giovanni Battista FerreroDepartment of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Italy.
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITCandiolo Cancer Institute · ITBambino Gesù Children's Hospital · ITCentre Hospitalier Universitaire Sainte-Justine · CAFondazione Ricerca Molinette · ITUniversity of Pavia · ITUniversity of Turin · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
The
Indexed as
Cardiomyopathy, HypertrophicExome SequencingFatal OutcomeFemaleHumansHypertension, PulmonaryInfant, NewbornMAP Kinase Kinase KinasesNoonan SyndromeProtein Kinase InhibitorsProto-Oncogene Proteins c-rafMAP Kinase Kinase KinasesProtein Kinase InhibitorsProto-Oncogene Proteins c-rafRaf1 protein, humanhypertrophic cardiomyopathyMEK-inhibitorNoonan syndromeRASopathiestherapeuticstranscriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.